| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 26 | 26 | 6 | 11 | 4.69 | .299 | 1.27 | 8.6 | 2.8 | 8.9 | 165.0 | 158 | 87 | 86 | 17 | 52 | 163 | 0 | 0 | 0 | 0 | 14 | 1 | 0 | 3.33 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 25 | 25 | 10 | 7 | 4.52 | .303 | 1.29 | 9.0 | 2.7 | 5.3 | 165.1 | 165 | 88 | 83 | 27 | 49 | 97 | 2 | 0 | 0 | 0 | 10 | 2 | 2 | 4.88 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 51 | 0 | 3 | 3 | 1.48 | .241 | 0.93 | 4.7 | 3.8 | 9.2 | 54.2 | 28 | 9 | 9 | 2 | 23 | 55 | 0 | 34 | 1 | 0 | 0 | 1 | 0 | 2.78 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 47 | 0 | 2 | 4 | 3.08 | .287 | 1.17 | 7.3 | 3.3 | 8.4 | 49.2 | 40 | 21 | 17 | 1 | 18 | 46 | 0 | 0 | 3 | 0 | 0 | 2 | 1 | 2.61 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 34 | 0 | 2 | 3 | 3.19 | .364 | 1.69 | 9.8 | 5.8 | 7.3 | 36.2 | 39 | 13 | 13 | 3 | 23 | 29 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.47 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 20 | 0 | 2 | 2 | 5.74 | .334 | 1.49 | 10.5 | 3.0 | 5.2 | 95.2 | 111 | 62 | 61 | 12 | 32 | 55 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.53 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 6 | 0 | 0 | 2 | 12.27 | .405 | 2.05 | 14.1 | 5.1 | 5.1 | 7.1 | 11 | 10 | 10 | 2 | 4 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 7.29 |