| SP | deGrom, J.deGrom, Jacob † # >> | 33 | 2021 | R | 100 | 29 | 29 | 13 | 9 | 3.18 | .266 | 1.08 | 7.7 | 2.0 | 9.9 | 201.0 | 173 | 73 | 71 | 17 | 44 | 220 | 2 | 0 | 0 | 0 | 20 | 2 | 0 | 2.60 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 29 | 29 | 10 | 12 | 4.85 | .326 | 1.43 | 9.9 | 3.0 | 8.2 | 172.2 | 190 | 101 | 93 | 22 | 57 | 156 | 0 | 0 | 0 | 0 | 15 | 3 | 1 | 3.90 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 28 | 28 | 8 | 13 | 4.62 | .328 | 1.44 | 9.7 | 3.3 | 4.4 | 208.2 | 225 | 120 | 107 | 27 | 76 | 101 | 2 | 0 | 0 | 0 | 14 | 5 | 1 | 4.88 |
| SP | Drysdale, D.Drysdale, Don † >> | 28 | 1964 | R | 58 | 27 | 27 | 13 | 7 | 4.29 | .325 | 1.43 | 9.0 | 3.9 | 5.4 | 205.2 | 206 | 107 | 98 | 20 | 88 | 124 | 9 | 0 | 0 | 1 | 14 | 3 | 7 | 4.39 |
| RP | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 77 | 0 | 7 | 5 | 3.05 | .263 | 1.06 | 6.5 | 3.1 | 8.5 | 106.1 | 76 | 40 | 36 | 9 | 37 | 100 | 0 | 10 | 5 | 0 | 0 | 1 | 2 | 3.29 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 50 | 0 | 4 | 7 | 5.37 | .332 | 1.49 | 10.0 | 3.6 | 8.3 | 53.2 | 59 | 32 | 32 | 8 | 21 | 49 | 0 | 7 | 4 | 0 | 0 | 0 | 0 | 4.30 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 34 | 0 | 3 | 2 | 4.93 | .325 | 1.38 | 9.3 | 3.4 | 9.5 | 34.2 | 35 | 19 | 19 | 5 | 13 | 36 | 0 | 1 | 3 | 0 | 0 | 2 | 2 | 4.12 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 30 | 0 | 1 | 1 | 2.08 | .262 | 1.04 | 7.4 | 2.1 | 7.1 | 34.2 | 28 | 8 | 8 | 3 | 8 | 27 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.35 |