| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 24 | 24 | 10 | 13 | 4.06 | .302 | 1.25 | 8.9 | 2.4 | 5.1 | 162.0 | 160 | 81 | 73 | 15 | 43 | 92 | 4 | 0 | 0 | 1 | 13 | 7 | 3 | 3.99 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 23 | 23 | 12 | 6 | 4.11 | .283 | 1.13 | 7.1 | 3.1 | 5.0 | 149.0 | 118 | 69 | 68 | 15 | 51 | 82 | 0 | 0 | 0 | 0 | 14 | 7 | 1 | 4.38 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 23 | 23 | 11 | 9 | 4.62 | .307 | 1.30 | 9.1 | 2.6 | 4.6 | 150.0 | 152 | 80 | 77 | 10 | 43 | 76 | 3 | 0 | 0 | 1 | 12 | 4 | 3 | 3.79 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 54 | 21 | 20 | 10 | 4 | 4.00 | .315 | 1.36 | 8.3 | 3.9 | 5.2 | 146.1 | 135 | 75 | 65 | 12 | 64 | 85 | 4 | 0 | 0 | 1 | 10 | 3 | 0 | 4.28 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 24 | 22 | 7 | 7 | 4.14 | .344 | 1.55 | 8.4 | 5.6 | 8.0 | 134.2 | 125 | 68 | 62 | 14 | 84 | 119 | 0 | 1 | 0 | 0 | 10 | 3 | 8 | 4.53 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 49 | 0 | 4 | 2 | 3.79 | .337 | 1.51 | 8.8 | 4.7 | 9.0 | 57.0 | 56 | 26 | 24 | 9 | 30 | 57 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 4.68 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 26 | 0 | 2 | 0 | 2.97 | .266 | 1.09 | 5.7 | 4.2 | 7.2 | 30.1 | 19 | 10 | 10 | 3 | 14 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.10 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 24 | 0 | 1 | 2 | 4.37 | .327 | 1.41 | 7.8 | 5.3 | 8.6 | 22.2 | 19 | 11 | 11 | 2 | 13 | 21 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.18 |
| SP | Chance, D.Chance, Dean >> | 23 | 1964 | R | 53 | 11 | 0 | 1 | 3 | 3.48 | .314 | 1.35 | 7.4 | 4.9 | 5.6 | 51.2 | 42 | 25 | 20 | 5 | 28 | 32 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.73 |
| CL | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 94 | 46 | 0 | 1 | 3 | 1.47 | .246 | 0.96 | 4.6 | 4.0 | 8.3 | 49.0 | 25 | 8 | 8 | 0 | 22 | 45 | 0 | 31 | 0 | 0 | 0 | 1 | 2 | 2.57 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 33 | 0 | 3 | 1 | 3.27 | .267 | 1.06 | 6.0 | 3.5 | 7.6 | 33.0 | 22 | 14 | 12 | 7 | 13 | 28 | 0 | 3 | 4 | 0 | 0 | 1 | 0 | 5.33 |