| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 6 | 6 | 2 | 3 | 3.95 | .301 | 1.29 | 8.3 | 3.3 | 10.1 | 41.0 | 38 | 18 | 18 | 4 | 15 | 46 | 1 | 0 | 0 | 0 | 4 | 0 | 1 | 3.12 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 6 | 6 | 3 | 1 | 2.94 | .310 | 1.35 | 7.9 | 4.2 | 4.6 | 49.0 | 43 | 17 | 16 | 7 | 23 | 25 | 2 | 0 | 0 | 0 | 5 | 0 | 0 | 5.24 |
| SP | Waddell, R.Waddell, Rube # >> | 29 | 1905 | L | 67 | 6 | 6 | 1 | 4 | 5.77 | .320 | 1.38 | 9.5 | 3.0 | 6.5 | 39.0 | 41 | 28 | 25 | 1 | 13 | 28 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 2.97 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 5 | 5 | 1 | 4 | 6.15 | .289 | 1.22 | 8.5 | 2.7 | 6.3 | 33.2 | 31 | 25 | 23 | 3 | 10 | 23 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 3.70 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 6 | 6 | 3 | 2 | 3.45 | .295 | 1.19 | 8.4 | 2.6 | 7.1 | 28.2 | 26 | 15 | 11 | 3 | 8 | 22 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.89 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 17 | 0 | 1 | 0 | 3.48 | .340 | 1.50 | 9.0 | 5.0 | 9.9 | 20.2 | 20 | 9 | 8 | 1 | 11 | 22 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 3.25 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 15 | 0 | 0 | 1 | 3.15 | .250 | 1.00 | 8.1 | 0.9 | 10.4 | 20.0 | 18 | 7 | 7 | 3 | 2 | 23 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.95 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 6 | 0 | 1 | 0 | 2.13 | .224 | 0.87 | 4.5 | 3.8 | 6.0 | 12.2 | 6 | 3 | 3 | 2 | 5 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.08 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 50 | 4 | 0 | 0 | 1 | 11.12 | .346 | 1.59 | 14.4 | 1.8 | 9.0 | 5.2 | 8 | 7 | 7 | 3 | 1 | 5 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 9.40 |