| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 85 | 23 | 23 | 2 | 7 | 3.69 | .285 | 1.16 | 7.5 | 3.0 | 6.3 | 97.2 | 81 | 42 | 40 | 9 | 32 | 68 | 0 | 0 | 0 | 0 | 1 | 4 | 3 | 3.92 |
| SP | Hamels, C.Hamels, Cole # >> | 25 | 2008 | L | 72 | 22 | 22 | 7 | 10 | 4.20 | .295 | 1.24 | 8.3 | 2.8 | 6.4 | 133.0 | 123 | 64 | 62 | 19 | 42 | 95 | 1 | 0 | 0 | 1 | 13 | 2 | 0 | 4.42 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 23 | 14 | 5 | 8 | 4.67 | .326 | 1.44 | 9.6 | 3.4 | 6.6 | 115.2 | 123 | 60 | 60 | 12 | 43 | 84 | 0 | 1 | 0 | 0 | 4 | 2 | 4 | 4.07 |
| CL | Balfour, G.Balfour, Grant † >> | 31 | 2008 | R | 90 | 48 | 0 | 1 | 2 | 2.35 | .241 | 0.89 | 4.8 | 3.4 | 10.2 | 53.2 | 28 | 14 | 14 | 3 | 20 | 60 | 0 | 22 | 1 | 0 | 0 | 3 | 2 | 2.77 |
| SU | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 56 | 0 | 1 | 1 | 2.93 | .293 | 1.19 | 8.9 | 1.9 | 8.9 | 70.2 | 69 | 24 | 23 | 9 | 15 | 69 | 0 | 6 | 4 | 0 | 0 | 4 | 2 | 3.51 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 61 | 0 | 6 | 2 | 5.06 | .325 | 1.42 | 9.7 | 3.2 | 7.2 | 74.2 | 80 | 42 | 42 | 16 | 26 | 59 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 5.35 |