| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 94 | 6 | 6 | 1 | 2 | 3.93 | .313 | 1.37 | 7.1 | 5.3 | 7.9 | 34.1 | 27 | 15 | 15 | 3 | 20 | 30 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 4.15 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 77 | 6 | 6 | 1 | 1 | 4.45 | .307 | 1.33 | 11.5 | 0.6 | 7.9 | 32.1 | 41 | 19 | 16 | 9 | 2 | 28 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 5.09 |
| SP | Arroyo, B.Arroyo, Bronson >> | 29 | 2006 | R | 21 | 3 | 3 | 1 | 0 | 7.24 | .379 | 1.76 | 13.2 | 3.5 | 9.0 | 13.2 | 19 | 11 | 11 | 3 | 5 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.38 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 15 | 0 | 2 | 0 | 1.62 | .242 | 0.90 | 5.1 | 3.4 | 6.8 | 16.2 | 9 | 4 | 3 | 1 | 6 | 12 | 0 | 6 | 1 | 0 | 0 | 1 | 2 | 3.63 |
| SU | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 87 | 16 | 0 | 1 | 2 | 6.08 | .375 | 1.80 | 10.4 | 6.2 | 6.9 | 13.1 | 15 | 15 | 9 | 3 | 9 | 10 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 6.54 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 73 | 17 | 0 | 3 | 3 | 11.49 | .427 | 2.17 | 16.8 | 3.6 | 10.8 | 15.2 | 28 | 20 | 20 | 2 | 6 | 18 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.73 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 54 | 13 | 0 | 0 | 0 | 1.20 | .308 | 1.33 | 7.8 | 4.2 | 9.0 | 15.0 | 13 | 3 | 2 | 1 | 7 | 15 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 3.27 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 6 | 3 | 1 | 2 | 3.97 | .327 | 1.41 | 7.4 | 5.7 | 7.0 | 22.2 | 18 | 12 | 10 | 3 | 14 | 17 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 5.27 |