| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 94 | 23 | 23 | 11 | 8 | 3.61 | .274 | 1.11 | 7.4 | 2.6 | 7.0 | 154.2 | 127 | 68 | 62 | 13 | 44 | 120 | 0 | 0 | 0 | 0 | 14 | 4 | 1 | 3.47 |
| SP | Mussina, M.Mussina, Mike # >> | 33 | 2001 | R | 68 | 22 | 22 | 8 | 5 | 4.81 | .314 | 1.36 | 10.1 | 2.2 | 9.1 | 140.1 | 157 | 76 | 75 | 25 | 34 | 142 | 0 | 0 | 0 | 0 | 10 | 2 | 6 | 4.06 |
| SP | Willis, D.Willis, Dontrelle # >> | 23 | 2005 | L | 49 | 22 | 22 | 6 | 8 | 5.24 | .358 | 1.60 | 11.1 | 3.3 | 5.8 | 144.1 | 178 | 90 | 84 | 22 | 53 | 92 | 2 | 0 | 0 | 0 | 8 | 10 | 1 | 5.02 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 33 | 22 | 22 | 6 | 6 | 5.33 | .359 | 1.65 | 9.5 | 5.5 | 6.8 | 104.2 | 110 | 65 | 62 | 18 | 63 | 79 | 0 | 0 | 0 | 0 | 3 | 3 | 4 | 5.63 |
| SP | Colon, B.Colon, Bartolo >> | 32 | 2005 | R | 22 | 22 | 21 | 8 | 5 | 5.90 | .354 | 1.59 | 11.4 | 3.0 | 6.0 | 129.2 | 163 | 90 | 85 | 19 | 43 | 86 | 0 | 0 | 0 | 0 | 8 | 7 | 5 | 4.74 |
| RP | Mota, G.Mota, Guillermo >> | 30 | 2003 | R | 50 | 47 | 0 | 5 | 3 | 3.52 | .299 | 1.23 | 7.7 | 3.4 | 7.3 | 64.0 | 55 | 25 | 25 | 9 | 24 | 52 | 0 | 4 | 0 | 0 | 0 | 3 | 0 | 4.47 |
| RP | Turnbow, D.Turnbow, Derrick >> | 27 | 2005 | R | 39 | 37 | 0 | 3 | 1 | 5.40 | .402 | 1.99 | 11.8 | 6.5 | 7.8 | 36.2 | 47 | 22 | 22 | 2 | 26 | 31 | 0 | 4 | 2 | 0 | 0 | 1 | 5 | 4.25 |
| RP | Corpas, M.Corpas, Manuel >> | 25 | 2007 | R | 26 | 33 | 0 | 5 | 0 | 2.25 | .271 | 1.09 | 7.2 | 2.7 | 5.7 | 44.0 | 35 | 14 | 11 | 4 | 13 | 28 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.86 |