| SP | Hernandez, F.Hernandez, Felix >> | 19 | 2005 | R | 96 | 25 | 25 | 12 | 5 | 4.31 | .315 | 1.33 | 8.2 | 3.8 | 6.5 | 152.1 | 138 | 85 | 73 | 19 | 64 | 110 | 2 | 0 | 0 | 0 | 15 | 8 | 3 | 4.60 |
| SP | Carpenter, C.Carpenter, Chris >> | 34 | 2009 | R | 80 | 24 | 24 | 10 | 6 | 4.25 | .314 | 1.34 | 8.6 | 3.5 | 5.4 | 150.1 | 143 | 78 | 71 | 16 | 59 | 90 | 2 | 0 | 0 | 1 | 11 | 4 | 2 | 4.45 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 23 | 23 | 8 | 6 | 5.08 | .331 | 1.47 | 10.9 | 2.4 | 6.6 | 118.2 | 143 | 67 | 67 | 20 | 31 | 87 | 1 | 0 | 0 | 1 | 10 | 2 | 0 | 4.57 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 85 | 23 | 23 | 6 | 4 | 3.13 | .268 | 1.09 | 6.3 | 3.5 | 6.5 | 97.2 | 68 | 36 | 34 | 13 | 38 | 70 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.51 |
| SP | Hamels, C.Hamels, Cole # >> | 25 | 2008 | L | 72 | 22 | 22 | 10 | 3 | 4.58 | .294 | 1.21 | 8.8 | 2.2 | 7.0 | 129.2 | 126 | 69 | 66 | 20 | 31 | 100 | 0 | 0 | 0 | 0 | 10 | 5 | 0 | 4.30 |
| CL | Soriano, R.Soriano, Rafael † >> | 24 | 2003 | R | 97 | 51 | 0 | 2 | 5 | 3.56 | .264 | 1.06 | 7.5 | 2.1 | 7.9 | 55.2 | 46 | 22 | 22 | 3 | 13 | 48 | 0 | 30 | 4 | 0 | 0 | 1 | 0 | 2.73 |
| SU | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 89 | 42 | 0 | 1 | 0 | 2.74 | .292 | 1.18 | 6.4 | 4.2 | 9.4 | 49.1 | 35 | 15 | 15 | 4 | 23 | 51 | 0 | 4 | 1 | 0 | 0 | 3 | 3 | 3.57 |
| RP | Percival, T.Percival, Troy † >> | 38 | 2007 | R | 84 | 53 | 0 | 10 | 2 | 3.91 | .244 | 0.97 | 6.2 | 2.5 | 6.5 | 78.1 | 54 | 36 | 34 | 13 | 22 | 56 | 0 | 2 | 2 | 0 | 0 | 0 | 5 | 4.58 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 51 | 0 | 2 | 3 | 3.49 | .328 | 1.41 | 9.0 | 3.9 | 10.3 | 56.2 | 56 | 23 | 22 | 6 | 24 | 64 | 0 | 0 | 4 | 0 | 0 | 3 | 0 | 3.55 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 43 | 0 | 4 | 2 | 3.73 | .306 | 1.30 | 8.1 | 3.8 | 6.5 | 50.2 | 45 | 21 | 21 | 8 | 21 | 36 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 4.96 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 3 | 0 | 0 | 1 | 5.40 | .500 | 3.00 | 45.0 | 0.0 | 9.0 | 1.2 | 5 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1.00 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 18 | 0 | 4 | 5 | 5.90 | .315 | 1.35 | 10.4 | 1.9 | 7.1 | 71.2 | 82 | 48 | 47 | 17 | 15 | 56 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 5.25 |