| SP | Johnson, R.Johnson, Randy † >> | 38 | 2001 | L | 97 | 23 | 23 | 12 | 7 | 3.91 | .309 | 1.31 | 8.7 | 3.2 | 10.1 | 158.2 | 152 | 72 | 69 | 18 | 56 | 178 | 4 | 0 | 0 | 0 | 14 | 5 | 2 | 3.39 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 22 | 22 | 5 | 6 | 6.63 | .337 | 1.51 | 10.9 | 2.7 | 5.8 | 96.1 | 116 | 72 | 71 | 18 | 29 | 62 | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 5.11 |
| SP | Nolasco, R.Nolasco, Ricky # >> | 26 | 2008 | R | 56 | 22 | 22 | 3 | 11 | 5.89 | .323 | 1.39 | 10.6 | 1.9 | 6.3 | 131.1 | 154 | 88 | 86 | 26 | 28 | 91 | 0 | 0 | 0 | 0 | 9 | 6 | 2 | 4.97 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 21 | 21 | 8 | 7 | 6.26 | .343 | 1.54 | 11.0 | 2.9 | 7.4 | 123.2 | 151 | 86 | 86 | 20 | 39 | 101 | 1 | 0 | 0 | 1 | 6 | 4 | 1 | 4.52 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 42 | 21 | 21 | 6 | 5 | 5.96 | .333 | 1.45 | 9.9 | 3.2 | 8.9 | 125.1 | 137 | 83 | 83 | 23 | 45 | 123 | 1 | 0 | 0 | 0 | 6 | 6 | 0 | 4.65 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 56 | 0 | 7 | 7 | 4.19 | .293 | 1.22 | 6.2 | 4.8 | 11.2 | 77.1 | 53 | 36 | 36 | 5 | 41 | 96 | 0 | 6 | 2 | 0 | 0 | 2 | 6 | 3.03 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 61 | 48 | 0 | 3 | 1 | 5.34 | .311 | 1.34 | 7.3 | 4.7 | 10.1 | 59.0 | 48 | 37 | 35 | 6 | 31 | 66 | 0 | 7 | 1 | 0 | 0 | 1 | 1 | 3.71 |
| RP | Linebrink, S.Linebrink, Scott >> | 28 | 2004 | R | 45 | 37 | 0 | 5 | 2 | 3.63 | .281 | 1.17 | 8.5 | 2.1 | 7.4 | 52.0 | 49 | 21 | 21 | 6 | 12 | 43 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.54 |
| RP | Kim, B.Kim, Byung-Hyun >> | 23 | 2002 | R | 37 | 41 | 0 | 4 | 1 | 7.47 | .388 | 1.90 | 12.2 | 5.1 | 9.7 | 37.1 | 50 | 31 | 31 | 8 | 21 | 40 | 0 | 4 | 0 | 0 | 0 | 0 | 2 | 5.35 |
| SP | Washburn, J.Washburn, Jarrod >> | 28 | 2002 | L | 32 | 14 | 0 | 3 | 2 | 7.62 | .386 | 1.88 | 12.5 | 4.5 | 6.9 | 26.0 | 36 | 22 | 22 | 7 | 13 | 20 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 6.46 |