| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 23 | 23 | 5 | 10 | 4.83 | .323 | 1.42 | 10.1 | 2.7 | 10.6 | 139.2 | 156 | 80 | 75 | 16 | 42 | 163 | 1 | 0 | 0 | 1 | 12 | 2 | 5 | 3.10 |
| SP | Bedard, E.Bedard, Erik # >> | 28 | 2007 | L | 80 | 23 | 23 | 6 | 11 | 4.75 | .330 | 1.46 | 8.8 | 4.4 | 9.9 | 144.0 | 140 | 76 | 76 | 20 | 70 | 159 | 1 | 0 | 0 | 1 | 10 | 3 | 4 | 4.12 |
| SP | Beckett, J.Beckett, Josh # >> | 27 | 2007 | R | 48 | 19 | 19 | 6 | 6 | 5.23 | .346 | 1.54 | 10.9 | 3.0 | 7.2 | 108.1 | 131 | 65 | 63 | 16 | 36 | 86 | 0 | 0 | 0 | 0 | 9 | 5 | 2 | 4.47 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 40 | 14 | 14 | 6 | 4 | 5.31 | .354 | 1.59 | 9.6 | 4.7 | 9.3 | 78.0 | 83 | 48 | 46 | 12 | 41 | 81 | 0 | 0 | 0 | 0 | 5 | 4 | 2 | 4.65 |
| SP | Verlander, J.Verlander, Justin # >> | 26 | 2009 | R | 42 | 15 | 15 | 6 | 5 | 5.34 | .355 | 1.63 | 11.5 | 3.2 | 9.4 | 91.0 | 116 | 57 | 54 | 18 | 32 | 95 | 0 | 0 | 0 | 0 | 5 | 2 | 5 | 4.60 |
| CL | Wagner, B.Wagner, Billy † >> | 32 | 2003 | L | 90 | 53 | 0 | 6 | 4 | 2.52 | .286 | 1.16 | 6.8 | 3.6 | 10.1 | 50.0 | 38 | 14 | 14 | 3 | 20 | 56 | 0 | 25 | 4 | 0 | 0 | 2 | 2 | 2.86 |
| RP | Fuentes, B.Fuentes, Brian >> | 33 | 2008 | L | 33 | 47 | 0 | 3 | 0 | 4.09 | .322 | 1.39 | 9.0 | 3.7 | 9.9 | 61.2 | 61 | 29 | 28 | 9 | 25 | 67 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 4.05 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 57 | 0 | 5 | 0 | 2.23 | .236 | 0.87 | 5.3 | 2.6 | 7.8 | 76.2 | 45 | 20 | 19 | 8 | 22 | 66 | 0 | 1 | 2 | 0 | 0 | 4 | 1 | 3.66 |
| RP | Donnelly, B.Donnelly, Brendan >> | 32 | 2003 | R | 39 | 38 | 0 | 5 | 3 | 3.66 | .343 | 1.54 | 10.2 | 3.9 | 7.4 | 46.2 | 52 | 20 | 19 | 5 | 20 | 38 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 4.13 |
| RP | Cordero, F.Cordero, Francisco >> | 32 | 2007 | R | 28 | 19 | 0 | 2 | 1 | 3.52 | .250 | 1.00 | 6.3 | 2.7 | 8.2 | 23.0 | 16 | 9 | 9 | 4 | 7 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.35 |
| RP | Seanez, R.Seanez, Rudy # >> | 37 | 2005 | R | 23 | 29 | 0 | 0 | 1 | 4.67 | .316 | 1.38 | 9.0 | 3.7 | 10.6 | 34.2 | 34 | 18 | 18 | 7 | 14 | 40 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.56 |
| RP | Wilson, B.Wilson, Brian >> | 27 | 2009 | R | 12 | 14 | 0 | 1 | 1 | 3.86 | .300 | 1.29 | 8.4 | 3.4 | 10.7 | 16.1 | 15 | 7 | 7 | 2 | 6 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.38 |
| SP | Lester, J.Lester, Jon # >> | 25 | 2009 | L | 19 | 17 | 9 | 4 | 5 | 5.54 | .346 | 1.52 | 10.6 | 3.1 | 9.1 | 89.1 | 105 | 59 | 55 | 15 | 31 | 90 | 0 | 0 | 0 | 0 | 3 | 6 | 4 | 4.42 |