| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 6 | 6 | 0 | 1 | 7.13 | .400 | 1.96 | 12.4 | 5.3 | 10.5 | 24.0 | 33 | 20 | 19 | 4 | 14 | 28 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.71 |
| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 83 | 6 | 6 | 3 | 2 | 3.72 | .327 | 1.43 | 9.3 | 3.8 | 5.8 | 36.1 | 37 | 17 | 15 | 4 | 15 | 23 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 4.50 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 66 | 6 | 6 | 0 | 0 | 6.44 | .385 | 1.81 | 11.5 | 5.0 | 5.6 | 29.1 | 37 | 21 | 21 | 3 | 16 | 18 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 4.97 |
| SP | Sabathia, C.Sabathia, CC >> | 28 | 2008 | L | 60 | 6 | 6 | 1 | 3 | 9.00 | .413 | 2.07 | 15.8 | 2.9 | 10.9 | 28.0 | 49 | 28 | 28 | 9 | 9 | 34 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 5.82 |
| SP | Shields, J.Shields, James >> | 26 | 2007 | R | 52 | 6 | 6 | 2 | 4 | 7.67 | .367 | 1.74 | 14.3 | 1.6 | 5.9 | 29.1 | 46 | 25 | 25 | 6 | 5 | 19 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 4.90 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 84 | 14 | 0 | 1 | 0 | 3.74 | .309 | 1.20 | 8.1 | 3.0 | 7.3 | 21.2 | 19 | 12 | 9 | 0 | 7 | 17 | 0 | 0 | 1 | 0 | 0 | 3 | 1 | 2.81 |
| RP | Politte, C.Politte, Cliff >> | 31 | 2005 | R | 65 | 17 | 0 | 3 | 1 | 2.42 | .272 | 1.03 | 5.3 | 4.1 | 5.3 | 22.1 | 13 | 6 | 6 | 3 | 10 | 13 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 5.23 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 52 | 16 | 0 | 2 | 1 | 5.31 | .299 | 1.28 | 6.8 | 5.0 | 7.2 | 20.1 | 15 | 12 | 12 | 5 | 11 | 16 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 6.30 |
| RP | Hawkins, L.Hawkins, LaTroy >> | 30 | 2002 | R | 40 | 16 | 0 | 1 | 1 | 4.64 | .256 | 1.03 | 6.0 | 3.4 | 6.0 | 21.1 | 14 | 11 | 11 | 1 | 8 | 14 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 3.43 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 49 | 7 | 0 | 0 | 1 | 10.54 | .431 | 2.27 | 12.5 | 9.0 | 8.3 | 13.2 | 18 | 16 | 16 | 6 | 13 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 10.15 |