| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 99 | 16 | 16 | 6 | 7 | 4.11 | .284 | 1.17 | 8.1 | 2.4 | 9.0 | 105.0 | 95 | 49 | 48 | 22 | 28 | 105 | 2 | 0 | 0 | 1 | 9 | 2 | 3 | 4.58 |
| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 83 | 16 | 16 | 9 | 5 | 4.15 | .320 | 1.36 | 8.8 | 3.5 | 6.6 | 99.2 | 97 | 48 | 46 | 16 | 39 | 73 | 1 | 0 | 0 | 1 | 11 | 5 | 3 | 4.96 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 77 | 16 | 16 | 6 | 7 | 5.25 | .321 | 1.40 | 10.1 | 2.6 | 7.1 | 94.1 | 105 | 56 | 55 | 16 | 27 | 74 | 1 | 0 | 0 | 0 | 9 | 2 | 0 | 4.56 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 67 | 16 | 16 | 4 | 4 | 7.83 | .387 | 1.84 | 12.4 | 4.2 | 5.9 | 79.1 | 109 | 71 | 69 | 24 | 37 | 52 | 0 | 0 | 0 | 0 | 2 | 4 | 2 | 7.19 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 50 | 16 | 15 | 6 | 4 | 5.66 | .337 | 1.45 | 9.6 | 3.4 | 6.5 | 89.0 | 95 | 56 | 56 | 16 | 34 | 64 | 0 | 0 | 0 | 0 | 5 | 7 | 0 | 5.28 |
| CL | Papelbon, J.Papelbon, Jonathan $ >> | 26 | 2006 | R | 93 | 37 | 0 | 0 | 6 | 4.83 | .276 | 1.15 | 8.1 | 2.2 | 11.2 | 41.0 | 37 | 22 | 22 | 7 | 10 | 51 | 0 | 19 | 1 | 0 | 0 | 0 | 1 | 3.46 |
| SU | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 86 | 41 | 0 | 3 | 0 | 1.38 | .247 | 0.94 | 4.8 | 3.8 | 6.0 | 45.2 | 24 | 8 | 7 | 1 | 19 | 30 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 3.36 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 82 | 44 | 0 | 1 | 1 | 5.27 | .319 | 1.38 | 10.5 | 2.1 | 8.8 | 42.2 | 49 | 25 | 25 | 11 | 10 | 41 | 0 | 0 | 2 | 0 | 0 | 1 | 2 | 5.24 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 44 | 0 | 2 | 0 | 2.96 | .291 | 1.19 | 7.7 | 3.2 | 6.4 | 48.2 | 41 | 16 | 16 | 2 | 17 | 34 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 3.31 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 54 | 38 | 0 | 6 | 0 | 3.32 | .303 | 1.30 | 9.7 | 2.3 | 9.5 | 40.2 | 43 | 17 | 15 | 5 | 10 | 42 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.28 |