| SP | Santana, J.Santana, Johan † $ >> | 25 | 2004 | L | 100 | 25 | 25 | 10 | 9 | 3.26 | .284 | 1.16 | 7.6 | 2.9 | 9.3 | 179.2 | 151 | 67 | 65 | 20 | 57 | 185 | 3 | 0 | 0 | 1 | 16 | 6 | 7 | 3.44 |
| SP | Bedard, E.Bedard, Erik >> | 28 | 2007 | L | 80 | 24 | 24 | 5 | 13 | 5.74 | .352 | 1.60 | 10.3 | 4.2 | 8.9 | 147.1 | 168 | 100 | 94 | 25 | 68 | 145 | 0 | 0 | 0 | 0 | 10 | 4 | 2 | 4.71 |
| SP | Williams, W.Williams, Woody † # >> | 36 | 2002 | R | 79 | 24 | 24 | 13 | 8 | 3.14 | .265 | 1.05 | 7.5 | 2.0 | 6.8 | 169.0 | 141 | 62 | 59 | 15 | 37 | 127 | 1 | 0 | 0 | 1 | 15 | 5 | 2 | 3.40 |
| SP | Maddux, G.Maddux, Greg # >> | 34 | 2000 | R | 58 | 24 | 24 | 8 | 11 | 5.67 | .349 | 1.58 | 11.4 | 2.9 | 6.5 | 166.2 | 210 | 107 | 105 | 31 | 53 | 120 | 1 | 0 | 0 | 0 | 9 | 5 | 2 | 5.03 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 63 | 0 | 3 | 1 | 4.93 | .339 | 1.50 | 10.2 | 3.3 | 9.1 | 84.0 | 95 | 48 | 46 | 14 | 31 | 85 | 0 | 7 | 4 | 0 | 0 | 3 | 3 | 4.36 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 87 | 57 | 0 | 2 | 4 | 3.01 | .267 | 1.09 | 6.4 | 3.6 | 7.3 | 68.2 | 48 | 24 | 23 | 6 | 27 | 55 | 0 | 11 | 1 | 0 | 0 | 0 | 0 | 3.72 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 77 | 38 | 0 | 2 | 5 | 4.17 | .310 | 1.30 | 7.8 | 4.0 | 9.0 | 45.1 | 39 | 25 | 21 | 6 | 20 | 45 | 0 | 3 | 4 | 0 | 0 | 2 | 0 | 4.20 |
| RP | Wheeler, D.Wheeler, Dan >> | 32 | 2009 | R | 65 | 27 | 0 | 1 | 2 | 3.33 | .283 | 1.19 | 8.0 | 2.7 | 6.7 | 27.0 | 24 | 11 | 10 | 5 | 8 | 20 | 0 | 3 | 2 | 0 | 0 | 0 | 1 | 4.81 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 57 | 24 | 0 | 1 | 3 | 3.72 | .269 | 1.10 | 9.0 | 0.9 | 9.0 | 29.0 | 29 | 15 | 12 | 9 | 3 | 29 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.34 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 51 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |