| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 16 | 16 | 10 | 3 | 2.92 | .289 | 1.19 | 8.0 | 2.8 | 10.1 | 114.0 | 101 | 39 | 37 | 12 | 35 | 128 | 0 | 0 | 0 | 0 | 11 | 3 | 3 | 3.12 |
| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 84 | 16 | 16 | 7 | 2 | 4.05 | .313 | 1.34 | 8.9 | 3.2 | 5.2 | 106.2 | 105 | 56 | 48 | 11 | 38 | 61 | 0 | 0 | 0 | 0 | 11 | 3 | 1 | 4.36 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 81 | 16 | 16 | 11 | 2 | 3.60 | .290 | 1.19 | 8.4 | 2.3 | 7.6 | 120.0 | 112 | 52 | 48 | 22 | 31 | 101 | 3 | 0 | 0 | 0 | 11 | 4 | 0 | 4.58 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 66 | 15 | 15 | 5 | 5 | 5.03 | .321 | 1.37 | 9.8 | 2.5 | 6.7 | 96.2 | 105 | 55 | 54 | 17 | 27 | 71 | 0 | 0 | 0 | 0 | 6 | 5 | 2 | 4.82 |
| SP | Millwood, K.Millwood, Kevin >> | 28 | 2002 | R | 51 | 15 | 15 | 5 | 6 | 5.89 | .352 | 1.60 | 10.5 | 3.9 | 6.1 | 84.0 | 98 | 55 | 55 | 19 | 36 | 57 | 0 | 0 | 0 | 0 | 6 | 3 | 0 | 5.98 |
| RP | Sasaki, K.Sasaki, Kazuhiro >> | 33 | 2001 | R | 63 | 26 | 0 | 0 | 1 | 4.35 | .279 | 1.16 | 7.8 | 2.6 | 9.0 | 31.0 | 27 | 15 | 15 | 5 | 9 | 31 | 0 | 6 | 2 | 0 | 0 | 0 | 3 | 3.97 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 48 | 25 | 0 | 1 | 0 | 4.13 | .300 | 1.26 | 9.0 | 2.5 | 6.2 | 32.2 | 32 | 15 | 15 | 4 | 9 | 22 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.19 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 45 | 15 | 0 | 2 | 4 | 3.91 | .405 | 1.96 | 9.8 | 7.8 | 7.8 | 23.0 | 25 | 10 | 10 | 0 | 20 | 20 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 4.13 |