| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 21 | 21 | 8 | 4 | 3.49 | .288 | 1.21 | 7.7 | 3.2 | 8.3 | 139.1 | 119 | 55 | 54 | 13 | 49 | 128 | 0 | 0 | 0 | 0 | 13 | 1 | 1 | 3.45 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 20 | 20 | 10 | 3 | 3.78 | .288 | 1.19 | 7.6 | 3.2 | 8.0 | 131.0 | 110 | 55 | 55 | 17 | 46 | 116 | 2 | 0 | 0 | 2 | 11 | 3 | 4 | 4.04 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 20 | 20 | 9 | 7 | 4.07 | .294 | 1.23 | 9.1 | 2.0 | 3.9 | 130.1 | 131 | 65 | 59 | 19 | 29 | 56 | 5 | 0 | 0 | 1 | 10 | 3 | 3 | 4.78 |
| SP | Fernandez, S.Fernandez, Sid # >> | 23 | 1985 | L | 49 | 20 | 20 | 7 | 2 | 3.34 | .306 | 1.29 | 7.3 | 4.4 | 7.3 | 129.1 | 104 | 50 | 48 | 9 | 63 | 104 | 0 | 0 | 0 | 0 | 13 | 4 | 0 | 3.85 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 20 | 18 | 6 | 7 | 4.96 | .332 | 1.48 | 8.0 | 5.4 | 4.4 | 110.2 | 98 | 61 | 61 | 12 | 66 | 54 | 0 | 0 | 0 | 0 | 7 | 1 | 1 | 5.26 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 94 | 60 | 0 | 6 | 4 | 2.33 | .230 | 0.90 | 4.6 | 3.5 | 9.0 | 92.2 | 47 | 26 | 24 | 8 | 36 | 92 | 0 | 14 | 4 | 0 | 0 | 0 | 0 | 3.30 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 51 | 0 | 6 | 4 | 1.97 | .226 | 0.86 | 4.9 | 2.9 | 10.1 | 68.2 | 37 | 17 | 15 | 3 | 22 | 76 | 0 | 8 | 0 | 0 | 0 | 1 | 0 | 2.35 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 28 | 0 | 2 | 2 | 4.68 | .310 | 1.32 | 7.6 | 4.5 | 9.8 | 32.2 | 27 | 18 | 17 | 5 | 16 | 35 | 0 | 3 | 4 | 0 | 0 | 1 | 1 | 4.44 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 19 | 0 | 2 | 1 | 2.92 | .267 | 1.05 | 6.8 | 3.0 | 9.8 | 24.2 | 18 | 9 | 8 | 1 | 8 | 26 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 2.50 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 9 | 1 | 2 | 2 | 4.76 | .427 | 2.18 | 9.5 | 10.1 | 7.9 | 17.0 | 18 | 9 | 9 | 1 | 19 | 15 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.53 |