| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 23 | 23 | 8 | 9 | 4.75 | .327 | 1.44 | 9.4 | 3.6 | 8.6 | 149.2 | 155 | 85 | 79 | 24 | 60 | 143 | 2 | 0 | 0 | 1 | 10 | 3 | 4 | 4.44 |
| SP | Brown, M.Brown, Mordecai † $ >> | 32 | 1908 | R | 84 | 23 | 23 | 15 | 4 | 3.01 | .287 | 1.20 | 7.5 | 3.3 | 4.6 | 173.2 | 145 | 67 | 58 | 15 | 64 | 88 | 6 | 0 | 0 | 3 | 16 | 1 | 2 | 4.24 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 46 | 0 | 5 | 3 | 4.25 | .287 | 1.20 | 6.9 | 4.1 | 9.4 | 42.1 | 32 | 20 | 20 | 5 | 19 | 44 | 0 | 5 | 4 | 0 | 0 | 0 | 0 | 3.81 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 75 | 0 | 2 | 3 | 3.84 | .265 | 1.08 | 7.2 | 2.6 | 8.2 | 65.2 | 52 | 34 | 28 | 11 | 19 | 59 | 0 | 8 | 2 | 0 | 0 | 0 | 4 | 4.26 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 25 | 0 | 3 | 1 | 5.13 | .358 | 1.67 | 8.7 | 6.6 | 11.4 | 26.1 | 25 | 15 | 15 | 5 | 19 | 33 | 0 | 6 | 3 | 0 | 0 | 0 | 1 | 5.15 |