| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 24 | 24 | 12 | 10 | 3.86 | .317 | 1.38 | 9.3 | 3.2 | 8.5 | 188.2 | 194 | 88 | 81 | 20 | 66 | 178 | 8 | 0 | 0 | 0 | 13 | 3 | 3 | 3.59 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 23 | 23 | 8 | 9 | 4.94 | .332 | 1.48 | 9.9 | 3.3 | 4.8 | 162.0 | 179 | 93 | 89 | 13 | 60 | 86 | 3 | 0 | 0 | 1 | 12 | 3 | 3 | 4.15 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 79 | 23 | 23 | 8 | 11 | 4.57 | .300 | 1.27 | 9.6 | 1.9 | 4.9 | 179.1 | 191 | 93 | 91 | 22 | 37 | 98 | 12 | 0 | 0 | 2 | 10 | 3 | 2 | 4.17 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 72 | 22 | 22 | 6 | 13 | 6.17 | .355 | 1.64 | 11.3 | 3.5 | 3.9 | 159.0 | 199 | 113 | 109 | 13 | 62 | 69 | 6 | 0 | 0 | 1 | 5 | 2 | 5 | 4.40 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 46 | 0 | 5 | 2 | 3.95 | .328 | 1.46 | 9.3 | 4.0 | 9.0 | 54.2 | 56 | 24 | 24 | 7 | 24 | 54 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 4.02 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 31 | 0 | 3 | 2 | 4.54 | .323 | 1.43 | 7.5 | 5.7 | 7.5 | 35.2 | 29 | 18 | 18 | 3 | 22 | 29 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 4.34 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 57 | 26 | 0 | 1 | 0 | 3.81 | .297 | 1.23 | 6.6 | 4.5 | 8.3 | 26.0 | 19 | 11 | 11 | 2 | 13 | 24 | 0 | 4 | 0 | 0 | 0 | 1 | 1 | 3.77 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 58 | 1 | 0 | 0 | 1 | - | 1.000 | - | - | - | - | 0.0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 10 | 0 | 1 | 0 | 3.71 | .370 | 1.71 | 11.6 | 3.7 | 2.1 | 17.0 | 22 | 7 | 7 | 1 | 7 | 4 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.71 |