| SP | Leonard, D.Leonard, Dutch $ >> | 22 | 1914 | L | 91 | 34 | 34 | 14 | 8 | 3.12 | .281 | 1.16 | 7.0 | 3.5 | 4.9 | 208.0 | 161 | 72 | 72 | 10 | 80 | 113 | 0 | 0 | 0 | 0 | 22 | 3 | 6 | 3.74 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 33 | 33 | 16 | 9 | 3.73 | .277 | 1.13 | 8.0 | 2.1 | 8.8 | 195.1 | 174 | 83 | 81 | 26 | 46 | 190 | 1 | 0 | 0 | 1 | 18 | 5 | 4 | 3.57 |
| SP | Guidry, R.Guidry, Ron † >> | 28 | 1978 | L | 77 | 33 | 33 | 19 | 8 | 3.01 | .274 | 1.11 | 7.2 | 2.8 | 5.5 | 251.1 | 201 | 86 | 84 | 16 | 79 | 152 | 15 | 0 | 0 | 5 | 22 | 4 | 7 | 3.61 |
| CL | Gagne, E.Gagne, Eric $ >> | 27 | 2003 | R | 98 | 82 | 0 | 3 | 3 | 3.27 | .278 | 1.15 | 7.1 | 3.3 | 8.3 | 110.0 | 87 | 42 | 40 | 13 | 40 | 102 | 0 | 15 | 5 | 0 | 0 | 0 | 1 | 3.77 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 70 | 0 | 5 | 6 | 2.44 | .272 | 1.11 | 8.3 | 1.8 | 8.9 | 84.2 | 77 | 23 | 23 | 10 | 17 | 83 | 0 | 12 | 5 | 0 | 0 | 1 | 3 | 3.21 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 36 | 0 | 4 | 1 | 2.40 | .239 | 0.94 | 6.6 | 2.0 | 7.2 | 41.1 | 30 | 11 | 11 | 2 | 9 | 33 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 2.68 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 16 | 0 | 2 | 2 | 4.08 | .303 | 1.30 | 6.4 | 5.8 | 9.0 | 17.2 | 12 | 8 | 8 | 5 | 11 | 17 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 6.76 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 32 | 0 | 4 | 0 | 3.36 | .279 | 1.16 | 7.5 | 3.0 | 6.5 | 72.1 | 60 | 28 | 27 | 9 | 24 | 52 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.18 |