| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 95 | 38 | 38 | 19 | 12 | 3.63 | .311 | 1.34 | 8.2 | 3.9 | 5.8 | 265.1 | 240 | 122 | 107 | 21 | 116 | 172 | 2 | 0 | 0 | 1 | 23 | 4 | 2 | 4.09 |
| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 93 | 37 | 37 | 9 | 18 | 3.83 | .296 | 1.23 | 7.2 | 3.8 | 6.5 | 244.1 | 196 | 111 | 104 | 31 | 104 | 177 | 1 | 0 | 0 | 1 | 23 | 8 | 7 | 4.58 |
| SP | Pfiester, J.Pfiester, Jack >> | 30 | 1908 | L | 84 | 37 | 37 | 13 | 18 | 4.19 | .311 | 1.34 | 8.7 | 3.4 | 5.5 | 268.2 | 258 | 133 | 125 | 34 | 101 | 165 | 10 | 0 | 0 | 2 | 18 | 5 | 7 | 4.60 |
| SP | Dobson, P.Dobson, Pat † >> | 29 | 1971 | R | 78 | 37 | 37 | 18 | 10 | 3.32 | .293 | 1.22 | 8.7 | 2.4 | 5.5 | 287.0 | 276 | 115 | 106 | 28 | 75 | 176 | 12 | 0 | 0 | 0 | 26 | 6 | 4 | 3.89 |
| RP | Borowski, J.Borowski, Joe >> | 32 | 2003 | R | 82 | 83 | 0 | 7 | 6 | 3.20 | .294 | 1.22 | 6.9 | 4.2 | 6.0 | 109.2 | 83 | 45 | 39 | 7 | 51 | 73 | 0 | 1 | 3 | 0 | 0 | 3 | 0 | 3.98 |
| RP | Farnsworth, K.Farnsworth, Kyle >> | 27 | 2003 | R | 80 | 77 | 0 | 7 | 4 | 3.09 | .281 | 1.13 | 6.3 | 3.9 | 9.9 | 84.1 | 59 | 30 | 29 | 7 | 36 | 92 | 0 | 8 | 3 | 0 | 0 | 4 | 5 | 3.32 |
| RP | Wohlers, M.Wohlers, Mark >> | 25 | 1995 | R | 74 | 41 | 0 | 4 | 3 | 2.70 | .298 | 1.25 | 6.8 | 4.5 | 10.6 | 40.0 | 30 | 12 | 12 | 6 | 20 | 47 | 0 | 3 | 2 | 0 | 0 | 1 | 1 | 4.18 |
| RP | Oliver, D.Oliver, Darren >> | 41 | 2011 | L | 68 | 30 | 0 | 1 | 0 | 4.45 | .336 | 1.52 | 9.6 | 4.2 | 7.2 | 30.1 | 32 | 15 | 15 | 5 | 14 | 24 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.97 |
| RP | Alvarez, J.Alvarez, Jose >> | 26 | 2015 | L | 62 | 26 | 0 | 1 | 0 | 2.53 | .220 | 0.81 | 6.5 | 0.8 | 7.9 | 32.0 | 23 | 10 | 9 | 4 | 3 | 28 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.25 |
| SP | Cuellar, M.Cuellar, Mike >> | 34 | 1971 | L | 71 | 2 | 0 | 1 | 0 | 0.00 | .000 | 0.00 | - | - | - | 0.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |