| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 97 | 31 | 31 | 9 | 15 | 4.26 | .295 | 1.24 | 8.8 | 2.3 | 6.3 | 203.0 | 198 | 102 | 96 | 30 | 53 | 141 | 7 | 0 | 0 | 0 | 19 | 4 | 6 | 4.37 |
| SP | Lackey, J.Lackey, John >> | 38 | 2016 | R | 92 | 33 | 33 | 5 | 18 | 5.46 | .337 | 1.50 | 10.1 | 3.5 | 6.9 | 197.2 | 220 | 129 | 120 | 28 | 77 | 151 | 1 | 0 | 0 | 0 | 11 | 4 | 6 | 4.55 |
| SP | Koosman, J.Koosman, Jerry >> | 27 | 1969 | L | 90 | 33 | 33 | 7 | 20 | 5.87 | .353 | 1.61 | 10.5 | 3.9 | 5.6 | 199.1 | 233 | 150 | 130 | 35 | 87 | 123 | 2 | 0 | 0 | 0 | 12 | 6 | 5 | 5.45 |
| SP | Garcia, F.Garcia, Freddy >> | 26 | 2001 | R | 80 | 33 | 33 | 13 | 13 | 4.03 | .317 | 1.38 | 8.4 | 4.0 | 5.3 | 225.2 | 210 | 120 | 101 | 21 | 101 | 132 | 3 | 0 | 0 | 1 | 20 | 3 | 2 | 4.43 |
| CL | Wheeler, D.Wheeler, Dan >> | 28 | 2005 | R | 90 | 76 | 0 | 2 | 7 | 3.53 | .294 | 1.22 | 8.0 | 3.1 | 7.3 | 81.2 | 72 | 33 | 32 | 9 | 28 | 66 | 0 | 29 | 6 | 0 | 0 | 2 | 0 | 3.93 |
| SU | Nelson, J.Nelson, Jeff >> | 35 | 2001 | R | 89 | 83 | 0 | 3 | 2 | 2.11 | .290 | 1.21 | 5.5 | 5.4 | 9.3 | 93.2 | 57 | 24 | 22 | 7 | 56 | 96 | 0 | 4 | 3 | 0 | 0 | 2 | 4 | 3.78 |
| RP | Feliz, N.Feliz, Neftali >> | 23 | 2011 | R | 78 | 91 | 0 | 5 | 4 | 5.01 | .340 | 1.52 | 8.3 | 5.3 | 6.9 | 106.0 | 98 | 64 | 59 | 12 | 63 | 81 | 0 | 3 | 5 | 0 | 0 | 3 | 2 | 4.81 |
| RP | Street, H.Street, Huston >> | 32 | 2015 | R | 70 | 80 | 0 | 6 | 5 | 5.22 | .322 | 1.41 | 9.2 | 3.6 | 6.2 | 98.1 | 100 | 64 | 57 | 11 | 39 | 68 | 0 | 1 | 4 | 0 | 0 | 1 | 8 | 4.30 |
| RP | Cahill, T.Cahill, Trevor >> | 28 | 2016 | R | 65 | 68 | 0 | 5 | 0 | 3.32 | .295 | 1.25 | 7.7 | 3.6 | 9.6 | 86.2 | 74 | 33 | 32 | 8 | 34 | 92 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 3.29 |