| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 11 | 11 | 5 | 4 | 4.64 | .286 | 1.19 | 8.6 | 2.1 | 9.6 | 64.0 | 61 | 33 | 33 | 11 | 15 | 68 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 3.86 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 12 | 11 | 1 | 4 | 10.37 | .388 | 1.88 | 14.4 | 2.7 | 8.5 | 37.1 | 59 | 44 | 43 | 14 | 11 | 35 | 1 | 0 | 0 | 0 | 2 | 1 | 4 | 7.00 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 84 | 11 | 11 | 5 | 3 | 4.79 | .290 | 1.23 | 8.7 | 2.3 | 4.1 | 62.0 | 60 | 34 | 33 | 8 | 16 | 28 | 2 | 0 | 0 | 0 | 6 | 0 | 2 | 4.55 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 78 | 10 | 10 | 4 | 3 | 4.70 | .299 | 1.28 | 9.6 | 2.0 | 6.1 | 59.1 | 63 | 35 | 31 | 11 | 13 | 40 | 3 | 0 | 0 | 0 | 5 | 0 | 2 | 4.73 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 28 | 0 | 1 | 3 | 2.95 | .257 | 0.98 | 6.0 | 3.0 | 7.0 | 36.2 | 24 | 12 | 12 | 3 | 12 | 28 | 0 | 9 | 1 | 0 | 0 | 2 | 1 | 3.69 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 31 | 0 | 1 | 0 | 7.41 | .376 | 1.67 | 10.5 | 4.9 | 10.5 | 37.2 | 43 | 34 | 31 | 10 | 20 | 43 | 0 | 1 | 0 | 0 | 0 | 5 | 0 | 6.22 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 88 | 30 | 0 | 2 | 3 | 5.18 | .348 | 1.60 | 9.0 | 5.4 | 10.4 | 40.0 | 40 | 25 | 23 | 8 | 24 | 46 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 5.10 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 23 | 0 | 2 | 0 | 5.88 | .333 | 1.50 | 9.0 | 4.5 | 8.7 | 26.0 | 26 | 17 | 17 | 6 | 13 | 25 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.58 |