| SP | Koufax, S.Koufax, Sandy † # >> | 30 | 1965 | L | 97 | 33 | 33 | 16 | 11 | 3.25 | .288 | 1.20 | 7.7 | 3.1 | 7.5 | 227.0 | 195 | 89 | 82 | 16 | 77 | 188 | 4 | 0 | 0 | 3 | 21 | 4 | 5 | 3.33 |
| SP | Leonard, D.Leonard, Dutch $ >> | 22 | 1914 | L | 91 | 32 | 32 | 14 | 6 | 3.30 | .287 | 1.18 | 7.3 | 3.3 | 4.9 | 207.0 | 167 | 79 | 76 | 11 | 77 | 112 | 3 | 0 | 0 | 2 | 21 | 6 | 1 | 3.81 |
| SP | Mathewson, C.Mathewson, Christy $$ >> | 29 | 1909 | R | 86 | 32 | 32 | 14 | 8 | 3.41 | .286 | 1.18 | 8.1 | 2.5 | 4.3 | 211.1 | 191 | 86 | 80 | 13 | 58 | 100 | 4 | 0 | 0 | 1 | 20 | 5 | 4 | 3.75 |
| SP | Snell, B.Snell, Blake † # $$ >> | 25 | 2018 | L | 81 | 31 | 31 | 18 | 5 | 3.16 | .254 | 1.01 | 5.9 | 3.2 | 7.8 | 199.1 | 131 | 70 | 70 | 18 | 71 | 172 | 2 | 0 | 0 | 2 | 19 | 2 | 10 | 3.55 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 41 | 27 | 27 | 9 | 9 | 4.79 | .323 | 1.43 | 8.9 | 4.0 | 7.0 | 154.0 | 152 | 87 | 82 | 18 | 68 | 120 | 0 | 0 | 0 | 0 | 10 | 0 | 8 | 4.29 |
| RP | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 94 | 83 | 0 | 9 | 3 | 1.99 | .248 | 0.95 | 4.9 | 3.7 | 9.6 | 113.1 | 62 | 27 | 25 | 9 | 46 | 120 | 0 | 12 | 4 | 0 | 0 | 4 | 1 | 3.24 |
| RP | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 88 | 79 | 0 | 9 | 2 | 2.30 | .254 | 1.00 | 7.5 | 1.6 | 7.6 | 97.2 | 81 | 27 | 25 | 6 | 17 | 82 | 0 | 14 | 1 | 0 | 0 | 2 | 0 | 2.70 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 59 | 0 | 1 | 6 | 3.23 | .308 | 1.30 | 8.4 | 3.4 | 8.7 | 61.1 | 57 | 24 | 22 | 4 | 23 | 59 | 0 | 10 | 3 | 0 | 0 | 2 | 2 | 3.15 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 34 | 0 | 5 | 1 | 1.79 | .292 | 1.21 | 5.6 | 5.4 | 11.3 | 40.1 | 25 | 8 | 8 | 2 | 24 | 50 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 3.03 |
| RP | Dibble, R.Dibble, Rob # >> | 26 | 1990 | R | 57 | 27 | 0 | 4 | 1 | 4.63 | .283 | 1.12 | 7.0 | 3.3 | 10.0 | 44.2 | 34 | 23 | 23 | 7 | 16 | 49 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 4.14 |