| SP | Arrieta, J.Arrieta, Jake $ >> | 29 | 2015 | R | 93 | 12 | 12 | 5 | 5 | 4.36 | .317 | 1.38 | 9.1 | 3.3 | 6.8 | 66.0 | 67 | 33 | 32 | 10 | 24 | 50 | 1 | 0 | 0 | 0 | 6 | 1 | 1 | 4.59 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 12 | 12 | 6 | 3 | 2.91 | .272 | 1.11 | 6.5 | 3.6 | 5.1 | 86.2 | 62 | 30 | 28 | 2 | 34 | 49 | 3 | 0 | 0 | 0 | 9 | 1 | 3 | 3.38 |
| SP | Mathewson, C.Mathewson, Christy # >> | 29 | 1909 | R | 85 | 12 | 12 | 3 | 5 | 4.44 | .277 | 1.15 | 8.4 | 1.9 | 5.2 | 75.0 | 70 | 37 | 37 | 8 | 16 | 43 | 0 | 0 | 0 | 0 | 6 | 0 | 2 | 3.88 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 12 | 12 | 6 | 1 | 2.43 | .263 | 1.06 | 5.8 | 3.8 | 7.5 | 92.2 | 59 | 25 | 25 | 10 | 39 | 77 | 2 | 0 | 0 | 2 | 9 | 1 | 0 | 4.04 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 30 | 0 | 5 | 2 | 3.43 | .239 | 0.90 | 5.3 | 2.9 | 10.4 | 44.2 | 26 | 19 | 17 | 3 | 14 | 51 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 2.66 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 30 | 0 | 1 | 3 | 2.78 | .236 | 0.93 | 8.0 | 0.5 | 8.2 | 35.2 | 31 | 11 | 11 | 4 | 2 | 32 | 0 | 8 | 1 | 0 | 0 | 0 | 0 | 2.83 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 20 | 0 | 1 | 1 | 3.68 | .275 | 1.14 | 6.5 | 3.7 | 8.2 | 22.0 | 16 | 9 | 9 | 4 | 9 | 20 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 4.77 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 78 | 12 | 0 | 1 | 0 | 1.26 | .306 | 1.33 | 9.0 | 3.2 | 9.0 | 14.1 | 14 | 2 | 2 | 0 | 5 | 14 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2.07 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 6 | 0 | 0 | 0 | 5.56 | .292 | 1.24 | 9.0 | 2.5 | 9.8 | 11.1 | 11 | 7 | 7 | 1 | 3 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.82 |