| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 19 | 19 | 8 | 4 | 3.74 | .273 | 1.10 | 7.4 | 2.5 | 8.6 | 125.0 | 103 | 54 | 52 | 15 | 35 | 119 | 0 | 0 | 0 | 0 | 13 | 3 | 0 | 3.57 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 79 | 18 | 18 | 7 | 9 | 4.18 | .296 | 1.26 | 8.9 | 2.4 | 6.4 | 140.0 | 139 | 68 | 65 | 21 | 37 | 99 | 10 | 0 | 0 | 1 | 9 | 1 | 4 | 4.35 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 18 | 18 | 4 | 12 | 6.01 | .350 | 1.59 | 10.5 | 3.8 | 4.1 | 124.1 | 145 | 91 | 83 | 15 | 53 | 57 | 3 | 0 | 0 | 0 | 7 | 3 | 4 | 5.01 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 58 | 17 | 17 | 8 | 9 | 5.80 | .348 | 1.58 | 10.5 | 3.8 | 5.5 | 102.1 | 119 | 70 | 66 | 13 | 43 | 62 | 0 | 0 | 0 | 0 | 6 | 2 | 2 | 4.76 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 44 | 0 | 2 | 4 | 5.37 | .326 | 1.40 | 10.2 | 2.5 | 9.7 | 53.2 | 60 | 33 | 32 | 10 | 15 | 57 | 0 | 3 | 2 | 0 | 0 | 3 | 2 | 4.32 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 40 | 0 | 3 | 2 | 3.35 | .313 | 1.34 | 8.6 | 3.6 | 8.3 | 48.1 | 46 | 19 | 18 | 6 | 19 | 44 | 0 | 5 | 3 | 0 | 0 | 1 | 0 | 4.04 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 18 | 0 | 1 | 1 | 2.18 | .303 | 1.31 | 5.4 | 6.8 | 8.1 | 20.2 | 12 | 5 | 5 | 0 | 15 | 18 | 0 | 1 | 0 | 0 | 0 | 0 | 5 | 3.45 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 9 | 0 | 0 | 1 | 3.86 | .314 | 1.37 | 9.8 | 3.3 | 9.0 | 11.2 | 12 | 5 | 5 | 1 | 4 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.27 |