| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 14 | 14 | 6 | 7 | 5.20 | .333 | 1.46 | 9.7 | 3.6 | 8.8 | 91.2 | 98 | 56 | 53 | 13 | 36 | 89 | 2 | 0 | 0 | 0 | 5 | 3 | 4 | 4.19 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 14 | 14 | 6 | 3 | 2.32 | .274 | 1.12 | 7.5 | 2.7 | 3.8 | 108.2 | 90 | 34 | 28 | 4 | 32 | 46 | 3 | 0 | 0 | 0 | 11 | 1 | 2 | 3.55 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 13 | 13 | 3 | 10 | 4.86 | .294 | 1.21 | 8.5 | 2.5 | 4.2 | 90.2 | 85 | 49 | 49 | 8 | 25 | 42 | 2 | 0 | 0 | 0 | 6 | 3 | 3 | 4.16 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 13 | 13 | 2 | 5 | 4.28 | .297 | 1.25 | 6.9 | 4.4 | 8.2 | 69.1 | 53 | 33 | 33 | 7 | 34 | 63 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 4.01 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 13 | 13 | 2 | 6 | 5.87 | .366 | 1.71 | 12.6 | 3.1 | 8.5 | 53.2 | 74 | 35 | 35 | 7 | 18 | 50 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.91 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 46 | 0 | 2 | 1 | 3.00 | .300 | 1.29 | 8.6 | 3.0 | 9.4 | 42.0 | 40 | 15 | 14 | 2 | 14 | 44 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 2.52 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 33 | 0 | 1 | 3 | 7.28 | .324 | 1.43 | 9.5 | 3.6 | 5.7 | 38.1 | 40 | 34 | 31 | 7 | 15 | 24 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 5.32 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 53 | 23 | 0 | 1 | 2 | 3.99 | .324 | 1.43 | 9.5 | 3.6 | 7.6 | 38.1 | 40 | 17 | 17 | 8 | 15 | 32 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.24 |