| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 13 | 13 | 7 | 2 | 2.33 | .290 | 1.22 | 7.6 | 3.4 | 9.5 | 89.0 | 75 | 24 | 23 | 2 | 34 | 94 | 1 | 0 | 0 | 0 | 10 | 0 | 0 | 2.33 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 13 | 13 | 6 | 3 | 3.57 | .298 | 1.26 | 8.7 | 2.8 | 9.2 | 85.2 | 82 | 34 | 34 | 12 | 26 | 87 | 1 | 0 | 0 | 0 | 9 | 1 | 2 | 3.74 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 78 | 12 | 12 | 2 | 4 | 6.37 | .348 | 1.57 | 10.7 | 3.5 | 5.4 | 65.0 | 77 | 48 | 46 | 12 | 25 | 39 | 1 | 0 | 0 | 0 | 3 | 2 | 0 | 5.45 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 13 | 12 | 3 | 3 | 4.91 | .321 | 1.39 | 10.0 | 2.6 | 4.2 | 73.1 | 81 | 47 | 40 | 9 | 21 | 34 | 1 | 1 | 0 | 0 | 5 | 2 | 2 | 4.62 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 37 | 0 | 1 | 1 | 4.72 | .318 | 1.37 | 8.2 | 4.2 | 9.5 | 34.1 | 31 | 18 | 18 | 3 | 16 | 36 | 0 | 16 | 2 | 0 | 0 | 1 | 0 | 3.53 |
| SU | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 39 | 0 | 3 | 2 | 4.64 | .326 | 1.45 | 10.7 | 2.6 | 8.8 | 42.2 | 50 | 26 | 22 | 6 | 12 | 41 | 0 | 1 | 7 | 0 | 0 | 0 | 0 | 3.76 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 34 | 0 | 3 | 4 | 3.82 | .289 | 1.17 | 7.5 | 3.2 | 8.8 | 37.2 | 31 | 16 | 16 | 3 | 13 | 36 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 3.32 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 28 | 0 | 3 | 1 | 3.27 | .261 | 1.06 | 7.1 | 2.5 | 8.7 | 33.0 | 26 | 12 | 12 | 5 | 9 | 32 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.85 |