| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 19 | 19 | 7 | 7 | 3.88 | .290 | 1.20 | 8.6 | 2.3 | 5.9 | 120.2 | 114 | 58 | 52 | 14 | 31 | 79 | 2 | 0 | 0 | 0 | 12 | 3 | 5 | 4.05 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 18 | 18 | 8 | 6 | 4.07 | .316 | 1.38 | 9.2 | 3.2 | 8.0 | 104.0 | 106 | 55 | 47 | 17 | 37 | 93 | 0 | 0 | 0 | 0 | 12 | 1 | 0 | 4.43 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 18 | 18 | 6 | 4 | 5.73 | .314 | 1.37 | 9.3 | 3.1 | 8.8 | 92.2 | 95 | 60 | 59 | 23 | 32 | 90 | 0 | 0 | 0 | 0 | 8 | 0 | 2 | 5.34 |
| SP | Hernandez, F.Hernandez, Felix # >> | 28 | 2014 | R | 80 | 18 | 18 | 5 | 6 | 6.09 | .339 | 1.49 | 9.6 | 3.8 | 7.6 | 99.0 | 106 | 71 | 67 | 13 | 42 | 84 | 1 | 0 | 0 | 0 | 6 | 4 | 6 | 4.40 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 42 | 0 | 6 | 2 | 1.63 | .221 | 0.83 | 4.6 | 2.9 | 9.0 | 55.1 | 28 | 11 | 10 | 2 | 18 | 55 | 0 | 14 | 2 | 0 | 0 | 1 | 1 | 2.51 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 48 | 0 | 1 | 4 | 4.72 | .325 | 1.45 | 10.5 | 2.6 | 8.8 | 55.1 | 64 | 30 | 29 | 12 | 16 | 54 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 4.75 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 36 | 0 | 3 | 0 | 3.86 | .277 | 1.15 | 7.6 | 2.9 | 9.4 | 44.1 | 37 | 20 | 19 | 6 | 14 | 46 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.64 |