| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 29 | 29 | 9 | 7 | 3.81 | .315 | 1.33 | 8.1 | 3.9 | 9.2 | 182.0 | 164 | 84 | 77 | 27 | 78 | 187 | 1 | 0 | 0 | 0 | 18 | 9 | 4 | 4.31 |
| SP | Perez, P.Perez, Pascual # >> | 31 | 1988 | R | 77 | 29 | 29 | 10 | 12 | 4.77 | .295 | 1.23 | 8.5 | 2.6 | 7.2 | 179.1 | 169 | 102 | 95 | 34 | 52 | 143 | 3 | 0 | 0 | 1 | 14 | 4 | 1 | 4.81 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 74 | 28 | 28 | 6 | 15 | 5.05 | .334 | 1.48 | 9.0 | 4.3 | 7.4 | 181.2 | 182 | 105 | 102 | 34 | 87 | 149 | 4 | 0 | 0 | 0 | 12 | 4 | 3 | 5.30 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 70 | 28 | 28 | 8 | 9 | 4.55 | .314 | 1.34 | 8.4 | 3.7 | 6.9 | 168.0 | 156 | 87 | 85 | 22 | 69 | 128 | 1 | 0 | 0 | 0 | 15 | 6 | 3 | 4.52 |
| CL | Green, C.Green, Chad † >> | 26 | 2017 | R | 94 | 58 | 0 | 5 | 10 | 3.76 | .307 | 1.28 | 7.0 | 4.6 | 9.8 | 69.1 | 54 | 29 | 29 | 9 | 35 | 75 | 0 | 32 | 6 | 0 | 0 | 3 | 0 | 4.17 |
| RP | Gallegos, G.Gallegos, Giovanny # >> | 27 | 2019 | R | 76 | 47 | 0 | 3 | 0 | 4.94 | .326 | 1.45 | 9.5 | 3.5 | 8.3 | 51.0 | 54 | 28 | 28 | 9 | 20 | 47 | 0 | 0 | 1 | 0 | 0 | 0 | 7 | 4.63 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 38 | 0 | 5 | 0 | 2.31 | .305 | 1.31 | 6.2 | 5.7 | 11.1 | 35.0 | 24 | 9 | 9 | 3 | 22 | 43 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.54 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 74 | 31 | 0 | 3 | 0 | 3.34 | .246 | 0.98 | 6.2 | 2.8 | 9.3 | 29.2 | 20 | 11 | 11 | 4 | 9 | 30 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 3.66 |
| SP | Higuera, T.Higuera, Teddy >> | 30 | 1988 | L | 65 | 19 | 0 | 1 | 1 | 4.85 | .335 | 1.49 | 9.2 | 4.4 | 7.7 | 55.2 | 56 | 30 | 30 | 7 | 27 | 47 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.47 |