| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 18 | 18 | 8 | 5 | 3.58 | .293 | 1.21 | 8.1 | 2.8 | 9.0 | 118.0 | 106 | 48 | 47 | 14 | 37 | 118 | 2 | 0 | 0 | 0 | 11 | 4 | 1 | 3.58 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 17 | 17 | 7 | 6 | 4.35 | .333 | 1.47 | 9.7 | 3.5 | 9.3 | 97.1 | 105 | 48 | 47 | 14 | 38 | 100 | 1 | 0 | 0 | 1 | 8 | 3 | 5 | 4.08 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 88 | 16 | 16 | 8 | 5 | 4.00 | .296 | 1.22 | 7.8 | 3.2 | 5.3 | 81.0 | 70 | 38 | 36 | 13 | 29 | 48 | 0 | 0 | 0 | 0 | 5 | 3 | 0 | 5.09 |
| SP | Flaherty, J.Flaherty, Jack >> | 23 | 2019 | R | 82 | 16 | 16 | 5 | 5 | 5.63 | .326 | 1.42 | 9.2 | 3.7 | 9.3 | 86.1 | 88 | 54 | 54 | 15 | 35 | 89 | 0 | 0 | 0 | 0 | 7 | 2 | 4 | 4.49 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 69 | 16 | 16 | 8 | 4 | 5.43 | .340 | 1.53 | 10.2 | 3.6 | 6.3 | 106.0 | 120 | 66 | 64 | 21 | 42 | 74 | 1 | 0 | 0 | 0 | 6 | 2 | 3 | 5.42 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 32 | 0 | 1 | 2 | 3.12 | .293 | 1.24 | 6.6 | 4.8 | 9.3 | 34.2 | 25 | 13 | 12 | 3 | 18 | 35 | 0 | 20 | 4 | 0 | 0 | 0 | 2 | 3.68 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 31 | 0 | 0 | 3 | 4.50 | .290 | 1.23 | 7.2 | 3.9 | 9.6 | 44.0 | 35 | 22 | 22 | 4 | 19 | 47 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 3.34 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 42 | 0 | 4 | 1 | 3.04 | .252 | 0.99 | 6.5 | 2.5 | 9.5 | 53.1 | 38 | 18 | 18 | 6 | 15 | 56 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 3.26 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 70 | 17 | 0 | 2 | 1 | 2.11 | .238 | 0.94 | 6.9 | 1.7 | 9.9 | 21.1 | 16 | 5 | 5 | 3 | 4 | 23 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.24 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 11 | 0 | 0 | 1 | 9.39 | .395 | 1.96 | 10.3 | 9.0 | 12.9 | 7.2 | 8 | 8 | 8 | 2 | 7 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 6.86 |
| SP | Candelaria, J.Candelaria, John >> | 33 | 1986 | L | 54 | 12 | 0 | 1 | 1 | 5.14 | .347 | 1.59 | 9.2 | 5.1 | 6.4 | 49.0 | 50 | 28 | 28 | 8 | 28 | 35 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5.41 |