| SP | Kershaw, C.Kershaw, Clayton † # >> | 28 | 2016 | L | 98 | 18 | 18 | 8 | 4 | 3.38 | .269 | 1.06 | 7.9 | 1.7 | 9.8 | 128.0 | 112 | 51 | 48 | 14 | 24 | 140 | 1 | 0 | 0 | 0 | 12 | 5 | 0 | 2.91 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 17 | 17 | 3 | 7 | 6.30 | .368 | 1.70 | 11.3 | 4.0 | 10.1 | 100.0 | 126 | 74 | 70 | 18 | 44 | 112 | 0 | 0 | 0 | 0 | 5 | 5 | 0 | 4.57 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 68 | 15 | 15 | 8 | 6 | 4.71 | .330 | 1.47 | 10.0 | 3.3 | 5.9 | 99.1 | 110 | 61 | 52 | 14 | 36 | 65 | 2 | 0 | 0 | 2 | 6 | 1 | 4 | 4.65 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 65 | 15 | 15 | 6 | 6 | 4.35 | .294 | 1.25 | 9.4 | 1.9 | 8.8 | 99.1 | 103 | 54 | 48 | 19 | 21 | 97 | 1 | 0 | 0 | 0 | 8 | 0 | 2 | 4.17 |
| SU | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 66 | 35 | 0 | 2 | 0 | 2.92 | .255 | 0.97 | 6.3 | 2.4 | 8.8 | 37.0 | 26 | 12 | 12 | 5 | 10 | 36 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 3.78 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 65 | 31 | 0 | 1 | 1 | 4.97 | .351 | 1.62 | 9.9 | 4.7 | 9.6 | 29.0 | 32 | 16 | 16 | 4 | 15 | 31 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 4.21 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 34 | 31 | 0 | 1 | 1 | 4.03 | .323 | 1.43 | 9.0 | 4.1 | 10.2 | 22.1 | 22 | 11 | 10 | 2 | 10 | 25 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.27 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 72 | 20 | 0 | 2 | 0 | 4.22 | .360 | 1.69 | 10.3 | 5.1 | 7.3 | 21.1 | 24 | 11 | 10 | 3 | 12 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.95 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 30 | 0 | 1 | 3 | 5.81 | .345 | 1.55 | 9.9 | 4.1 | 8.1 | 31.0 | 34 | 24 | 20 | 6 | 14 | 28 | 0 | 4 | 2 | 0 | 0 | 1 | 2 | 5.16 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 90 | 18 | 0 | 0 | 3 | 9.00 | .350 | 1.54 | 11.1 | 2.8 | 10.4 | 13.0 | 16 | 13 | 13 | 5 | 4 | 15 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 6.85 |