| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 26 | 26 | 11 | 9 | 3.30 | .280 | 1.13 | 7.6 | 2.7 | 10.5 | 163.2 | 137 | 65 | 60 | 23 | 48 | 190 | 0 | 0 | 0 | 0 | 19 | 6 | 0 | 3.50 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 28 | 28 | 14 | 7 | 4.79 | .335 | 1.45 | 9.0 | 4.1 | 8.6 | 173.0 | 173 | 100 | 92 | 22 | 78 | 166 | 0 | 0 | 0 | 0 | 14 | 10 | 5 | 4.26 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 83 | 28 | 28 | 11 | 8 | 4.23 | .306 | 1.30 | 8.1 | 3.6 | 7.1 | 178.2 | 161 | 92 | 84 | 17 | 72 | 140 | 3 | 0 | 0 | 0 | 18 | 3 | 3 | 3.93 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 65 | 27 | 27 | 12 | 8 | 4.92 | .326 | 1.43 | 9.7 | 3.2 | 9.3 | 172.0 | 185 | 94 | 94 | 31 | 61 | 177 | 1 | 0 | 0 | 0 | 14 | 4 | 2 | 4.42 |
| CL | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 90 | 60 | 0 | 3 | 4 | 2.34 | .276 | 1.14 | 7.3 | 3.2 | 7.9 | 57.2 | 46 | 15 | 15 | 7 | 20 | 50 | 0 | 36 | 4 | 0 | 0 | 0 | 0 | 3.89 |
| SU | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 64 | 51 | 0 | 2 | 2 | 3.31 | .272 | 1.08 | 7.1 | 2.8 | 8.3 | 51.2 | 40 | 20 | 19 | 5 | 16 | 47 | 0 | 1 | 1 | 0 | 0 | 2 | 2 | 3.49 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 81 | 36 | 0 | 3 | 1 | 3.60 | .277 | 1.13 | 7.9 | 2.3 | 10.1 | 40.0 | 35 | 18 | 16 | 7 | 10 | 45 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.85 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 73 | 43 | 0 | 5 | 3 | 4.58 | .376 | 1.81 | 10.2 | 6.2 | 9.9 | 39.1 | 44 | 21 | 20 | 3 | 27 | 43 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 3.87 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 96 | 26 | 0 | 0 | 1 | 5.47 | .325 | 1.44 | 9.3 | 3.8 | 13.5 | 26.1 | 27 | 19 | 16 | 6 | 11 | 39 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.27 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 57 | 0 | 0 | 5 | 5.95 | .306 | 1.28 | 7.7 | 3.9 | 10.3 | 42.1 | 36 | 28 | 28 | 8 | 18 | 48 | 0 | 1 | 1 | 0 | 0 | 2 | 5 | 4.62 |
| RP | Betances, D.Betances, Dellin # >> | 26 | 2014 | R | 92 | 39 | 0 | 1 | 3 | 5.66 | .319 | 1.35 | 7.7 | 4.6 | 8.6 | 41.1 | 35 | 26 | 26 | 7 | 21 | 39 | 0 | 3 | 4 | 0 | 0 | 2 | 0 | 5.00 |