| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 93 | 20 | 20 | 6 | 8 | 4.22 | .317 | 1.38 | 9.1 | 3.3 | 8.9 | 134.1 | 136 | 73 | 63 | 11 | 49 | 133 | 2 | 0 | 0 | 0 | 11 | 2 | 3 | 3.22 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 19 | 19 | 10 | 5 | 3.59 | .282 | 1.15 | 8.2 | 2.2 | 5.7 | 140.1 | 127 | 62 | 56 | 15 | 34 | 89 | 4 | 0 | 0 | 1 | 11 | 4 | 2 | 3.94 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 19 | 19 | 10 | 4 | 3.11 | .269 | 1.10 | 7.2 | 2.8 | 5.2 | 124.1 | 99 | 43 | 43 | 9 | 38 | 72 | 0 | 0 | 0 | 0 | 11 | 0 | 1 | 3.70 |
| SP | Gooden, D.Gooden, Dwight † >> | 21 | 1985 | R | 68 | 18 | 18 | 10 | 4 | 3.48 | .289 | 1.21 | 8.3 | 2.6 | 6.2 | 147.1 | 136 | 62 | 57 | 13 | 42 | 102 | 6 | 0 | 0 | 0 | 9 | 2 | 0 | 3.66 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 12 | 12 | 6 | 4 | 3.62 | .302 | 1.29 | 7.1 | 4.4 | 7.2 | 77.0 | 61 | 33 | 31 | 8 | 38 | 62 | 1 | 0 | 0 | 1 | 7 | 1 | 1 | 4.26 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 51 | 0 | 3 | 2 | 1.70 | .242 | 0.94 | 6.1 | 2.4 | 8.7 | 63.2 | 43 | 13 | 12 | 4 | 17 | 61 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 2.75 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 24 | 0 | 1 | 2 | 5.64 | .343 | 1.57 | 9.4 | 4.9 | 4.9 | 22.1 | 23 | 14 | 14 | 4 | 12 | 12 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 5.91 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 16 | 0 | 0 | 1 | 4.11 | .292 | 1.24 | 7.8 | 3.6 | 10.2 | 15.1 | 13 | 7 | 7 | 2 | 6 | 17 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.67 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 9 | 0 | 1 | 2 | 5.19 | .316 | 1.38 | 9.0 | 4.5 | 11.3 | 8.2 | 8 | 5 | 5 | 2 | 4 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.25 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 4 | 0 | 1 | 1 | 0.00 | .343 | 1.57 | 9.0 | 6.4 | 2.6 | 7.2 | 7 | 7 | 0 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.57 |