| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 21 | 21 | 6 | 10 | 5.03 | .302 | 1.26 | 9.2 | 2.2 | 3.6 | 137.2 | 140 | 77 | 77 | 21 | 34 | 55 | 5 | 0 | 0 | 2 | 9 | 5 | 4 | 5.04 |
| SP | Young, C.Young, Cy † # >> | 41 | 1908 | R | 66 | 20 | 20 | 13 | 2 | 3.42 | .297 | 1.24 | 9.7 | 1.5 | 4.2 | 160.1 | 172 | 65 | 61 | 16 | 27 | 74 | 11 | 0 | 0 | 2 | 13 | 4 | 1 | 3.96 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 20 | 20 | 1 | 6 | 6.52 | .357 | 1.65 | 10.0 | 5.0 | 7.6 | 78.2 | 87 | 58 | 57 | 11 | 43 | 66 | 0 | 0 | 0 | 0 | 1 | 1 | 5 | 4.83 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 58 | 19 | 19 | 6 | 8 | 6.55 | .352 | 1.60 | 10.9 | 3.7 | 4.4 | 101.2 | 122 | 78 | 74 | 14 | 41 | 49 | 0 | 0 | 0 | 0 | 7 | 3 | 1 | 5.14 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 49 | 0 | 4 | 0 | 3.30 | .260 | 1.03 | 6.2 | 3.0 | 8.4 | 71.0 | 49 | 26 | 26 | 10 | 24 | 66 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 4.07 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 39 | 0 | 5 | 5 | 3.67 | .283 | 1.13 | 7.0 | 3.2 | 8.2 | 54.0 | 42 | 23 | 22 | 6 | 19 | 49 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 3.85 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 41 | 0 | 1 | 4 | 4.24 | .354 | 1.61 | 11.1 | 3.4 | 9.2 | 51.0 | 63 | 25 | 24 | 9 | 19 | 52 | 0 | 4 | 2 | 0 | 0 | 2 | 3 | 4.49 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 38 | 0 | 5 | 1 | 2.96 | .295 | 1.24 | 7.3 | 3.9 | 5.5 | 70.0 | 57 | 26 | 23 | 4 | 30 | 43 | 0 | 3 | 0 | 0 | 0 | 1 | 3 | 3.84 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 50 | 22 | 0 | 2 | 4 | 4.91 | .308 | 1.31 | 9.8 | 2.3 | 8.8 | 36.2 | 39 | 20 | 20 | 4 | 9 | 35 | 0 | 3 | 1 | 0 | 0 | 1 | 1 | 3.33 |