| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 20 | 20 | 5 | 11 | 4.89 | .312 | 1.34 | 8.7 | 3.4 | 8.4 | 123.1 | 119 | 70 | 67 | 22 | 46 | 115 | 0 | 0 | 0 | 0 | 10 | 3 | 2 | 4.65 |
| SP | Brown, M.Brown, Mordecai # >> | 32 | 1908 | R | 85 | 20 | 20 | 10 | 5 | 4.11 | .279 | 1.13 | 8.1 | 2.2 | 4.2 | 146.2 | 131 | 69 | 67 | 11 | 35 | 68 | 5 | 0 | 0 | 1 | 10 | 4 | 4 | 3.85 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 19 | 19 | 9 | 6 | 4.90 | .319 | 1.40 | 9.1 | 3.5 | 5.0 | 134.0 | 135 | 76 | 73 | 17 | 52 | 75 | 5 | 0 | 0 | 0 | 6 | 1 | 2 | 4.72 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 48 | 0 | 2 | 4 | 3.74 | .257 | 1.02 | 7.1 | 2.1 | 10.3 | 67.1 | 53 | 28 | 28 | 9 | 16 | 77 | 0 | 4 | 3 | 0 | 0 | 1 | 1 | 3.21 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 41 | 0 | 2 | 5 | 3.16 | .300 | 1.27 | 7.8 | 3.7 | 9.4 | 51.1 | 44 | 19 | 18 | 5 | 21 | 53 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 3.49 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 41 | 0 | 2 | 3 | 5.53 | .348 | 1.52 | 8.6 | 5.4 | 7.4 | 40.2 | 38 | 26 | 25 | 3 | 24 | 33 | 0 | 4 | 0 | 0 | 0 | 3 | 0 | 4.35 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 54 | 21 | 0 | 0 | 0 | 3.29 | .287 | 1.21 | 7.3 | 3.7 | 8.3 | 27.1 | 22 | 13 | 10 | 6 | 11 | 25 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.26 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 4 | 0 | 1 | 1 | 0.00 | .321 | 1.42 | 7.5 | 6.0 | 6.0 | 6.1 | 5 | 1 | 0 | 0 | 4 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.67 |