| SP | Jimenez, U.Jimenez, Ubaldo † >> | 26 | 2010 | R | 61 | 37 | 37 | 21 | 8 | 3.55 | .298 | 1.27 | 7.5 | 3.9 | 6.5 | 251.1 | 208 | 100 | 99 | 20 | 110 | 182 | 5 | 0 | 0 | 4 | 23 | 2 | 10 | 3.92 |
| SP | De La Rosa, J.De La Rosa, Jorge >> | 30 | 2011 | L | 54 | 35 | 35 | 0 | 6 | 3.55 | .305 | 1.28 | 7.1 | 4.5 | 6.5 | 91.1 | 72 | 38 | 36 | 9 | 45 | 66 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 4.42 |
| SP | Chacin, J.Chacin, Jhoulys # >> | 22 | 2010 | R | 47 | 34 | 34 | 13 | 11 | 4.77 | .311 | 1.34 | 8.1 | 4.0 | 8.0 | 175.1 | 158 | 96 | 93 | 26 | 77 | 155 | 0 | 0 | 0 | 0 | 9 | 2 | 5 | 4.51 |
| SP | Thomson, J.Thomson, John # >> | 28 | 2001 | R | 49 | 33 | 33 | 0 | 6 | 5.58 | .340 | 1.52 | 9.7 | 4.0 | 6.4 | 79.0 | 85 | 50 | 49 | 10 | 35 | 56 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.63 |
| SP | Marquez, G.Marquez, German >> | 23 | 2018 | R | 48 | 31 | 31 | 14 | 8 | 4.46 | .325 | 1.43 | 9.3 | 3.5 | 8.9 | 181.2 | 188 | 93 | 90 | 19 | 71 | 179 | 0 | 0 | 0 | 0 | 15 | 4 | 5 | 3.63 |
| RP | Ottavino, A.Ottavino, Adam >> | 32 | 2018 | R | 70 | 90 | 0 | 8 | 4 | 3.65 | .316 | 1.37 | 7.5 | 4.9 | 9.5 | 120.2 | 100 | 51 | 49 | 8 | 65 | 126 | 0 | 8 | 6 | 0 | 0 | 2 | 8 | 3.44 |
| RP | Miller, J.Miller, Justin >> | 28 | 2015 | R | 55 | 76 | 0 | 2 | 1 | 3.52 | .317 | 1.36 | 7.6 | 4.6 | 9.7 | 92.0 | 78 | 36 | 36 | 7 | 47 | 99 | 0 | 6 | 1 | 0 | 0 | 3 | 4 | 3.47 |
| RP | Street, H.Street, Huston >> | 26 | 2009 | R | 54 | 70 | 0 | 6 | 1 | 3.29 | .275 | 1.13 | 7.6 | 2.7 | 7.8 | 95.2 | 80 | 42 | 35 | 10 | 28 | 82 | 0 | 7 | 1 | 0 | 0 | 1 | 0 | 3.56 |
| RP | Betancourt, R.Betancourt, Rafael >> | 36 | 2011 | R | 64 | 38 | 0 | 4 | 2 | 4.12 | .310 | 1.35 | 9.5 | 2.8 | 9.2 | 39.1 | 41 | 20 | 18 | 5 | 12 | 40 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 3.54 |
| RP | DeJean, M.DeJean, Mike >> | 35 | 2005 | R | 39 | 26 | 0 | 2 | 2 | 4.91 | .347 | 1.60 | 7.9 | 6.8 | 7.6 | 25.2 | 22 | 14 | 14 | 4 | 19 | 21 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 5.68 |
| RP | Kahnle, T.Kahnle, Tommy >> | 24 | 2014 | R | 30 | 37 | 0 | 0 | 2 | 3.65 | .296 | 1.20 | 6.5 | 4.3 | 7.0 | 44.1 | 32 | 19 | 18 | 3 | 21 | 34 | 0 | 1 | 0 | 0 | 0 | 3 | 2 | 3.98 |