| SP | Hellickson, J.Hellickson, Jeremy >> | 29 | 2016 | R | 50 | 25 | 25 | 11 | 5 | 4.20 | .309 | 1.33 | 9.1 | 2.9 | 6.2 | 152.0 | 153 | 80 | 71 | 23 | 49 | 104 | 1 | 0 | 0 | 1 | 12 | 2 | 3 | 4.61 |
| SP | Jacobs, E.Jacobs, Elmer >> | 26 | 1918 | R | 58 | 24 | 24 | 9 | 9 | 5.08 | .326 | 1.45 | 9.1 | 4.0 | 4.7 | 141.2 | 143 | 91 | 80 | 19 | 62 | 73 | 2 | 0 | 0 | 0 | 11 | 1 | 3 | 5.06 |
| SP | Nichols, K.Nichols, Kid >> | 36 | 1905 | R | 45 | 23 | 23 | 9 | 9 | 4.71 | .327 | 1.42 | 10.1 | 2.8 | 5.0 | 158.2 | 177 | 94 | 83 | 18 | 49 | 87 | 5 | 0 | 0 | 0 | 12 | 5 | 6 | 4.41 |
| SP | Haddix, H.Haddix, Harvey >> | 31 | 1956 | L | 39 | 23 | 23 | 11 | 7 | 5.00 | .328 | 1.44 | 9.5 | 3.5 | 5.1 | 145.2 | 153 | 88 | 81 | 24 | 57 | 82 | 1 | 0 | 0 | 0 | 9 | 3 | 5 | 5.26 |
| CL | Hoffman, J.Hoffman, Jeff † >> | 30 | 2023 | R | 74 | 55 | 0 | 4 | 7 | 2.36 | .231 | 0.88 | 5.3 | 2.7 | 7.3 | 53.1 | 31 | 16 | 14 | 8 | 16 | 43 | 0 | 32 | 1 | 0 | 0 | 1 | 1 | 4.30 |
| RP | Bastardo, A.Bastardo, Antonio >> | 26 | 2011 | L | 78 | 65 | 0 | 6 | 2 | 2.07 | .227 | 0.88 | 5.4 | 2.6 | 7.7 | 82.2 | 49 | 23 | 19 | 7 | 24 | 70 | 0 | 1 | 2 | 0 | 0 | 0 | 3 | 3.28 |
| RP | Garber, G.Garber, Gene >> | 31 | 1978 | R | 54 | 50 | 0 | 2 | 1 | 2.40 | .287 | 1.19 | 7.6 | 3.2 | 6.2 | 78.2 | 66 | 26 | 21 | 5 | 28 | 54 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.56 |
| RP | De Fratus, J.De Fratus, Justin >> | 26 | 2014 | R | 34 | 35 | 0 | 1 | 0 | 2.61 | .265 | 1.05 | 7.6 | 1.9 | 5.0 | 38.0 | 32 | 15 | 11 | 4 | 8 | 21 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.97 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 35 | 2015 | R | 48 | 22 | 0 | 3 | 3 | 3.86 | .278 | 1.16 | 7.8 | 2.7 | 7.0 | 23.1 | 20 | 14 | 10 | 3 | 7 | 18 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.04 |
| RP | Schrenk, S.Schrenk, Steve >> | 31 | 1999 | R | 28 | 24 | 0 | 2 | 0 | 4.15 | .326 | 1.45 | 9.3 | 3.9 | 5.7 | 30.1 | 31 | 16 | 14 | 4 | 13 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 4.77 |