| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 10 | 10 | 6 | 4 | 2.46 | .237 | 0.93 | 6.4 | 2.0 | 7.2 | 80.1 | 57 | 26 | 22 | 7 | 18 | 64 | 4 | 0 | 0 | 0 | 7 | 0 | 0 | 3.21 |
| SP | Maddux, G.Maddux, Greg $ >> | 29 | 1995 | R | 89 | 8 | 8 | 4 | 3 | 4.73 | .269 | 1.09 | 8.0 | 1.9 | 4.8 | 53.1 | 47 | 30 | 28 | 11 | 11 | 28 | 2 | 0 | 0 | 0 | 4 | 1 | 0 | 5.32 |
| SP | Brown, M.Brown, Mordecai $ >> | 32 | 1908 | R | 85 | 9 | 9 | 6 | 1 | 3.07 | .241 | 0.93 | 6.0 | 2.3 | 4.2 | 73.1 | 49 | 26 | 25 | 9 | 19 | 34 | 1 | 0 | 0 | 0 | 6 | 2 | 1 | 4.53 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 8 | 8 | 5 | 3 | 3.86 | .319 | 1.38 | 9.0 | 3.5 | 8.1 | 51.1 | 51 | 25 | 22 | 5 | 20 | 46 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 3.71 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 13 | 0 | 0 | 0 | 0.57 | .254 | 1.02 | 4.8 | 4.8 | 7.8 | 15.2 | 8 | 3 | 1 | 0 | 8 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.87 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 10 | 0 | 0 | 0 | 5.56 | .370 | 1.76 | 9.0 | 7.4 | 9.0 | 11.1 | 11 | 7 | 7 | 1 | 9 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.64 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 66 | 6 | 0 | 0 | 0 | 5.63 | .314 | 1.38 | 7.9 | 4.5 | 6.8 | 8.0 | 7 | 5 | 5 | 3 | 4 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 7.88 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 3 | 0 | 0 | 0 | 1.80 | .286 | 1.20 | 5.4 | 5.4 | 7.2 | 5.0 | 3 | 1 | 1 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.20 |
| CL | Doolittle, S.Doolittle, Sean $ >> | 31 | 2018 | L | 99 | 13 | 0 | 1 | 1 | 3.21 | .300 | 1.21 | 6.4 | 4.5 | 12.2 | 14.0 | 10 | 5 | 5 | 3 | 7 | 19 | 0 | 7 | 1 | 0 | 0 | 1 | 0 | 4.79 |