| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 15 | 15 | 4 | 7 | 4.36 | .309 | 1.32 | 8.2 | 3.8 | 8.3 | 117.2 | 106 | 58 | 57 | 13 | 49 | 108 | 6 | 0 | 0 | 0 | 6 | 3 | 4 | 3.93 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 15 | 15 | 7 | 8 | 3.39 | .283 | 1.17 | 8.0 | 2.6 | 5.4 | 119.1 | 106 | 46 | 45 | 13 | 34 | 71 | 7 | 0 | 0 | 1 | 10 | 1 | 0 | 4.11 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 14 | 14 | 2 | 6 | 4.63 | .296 | 1.26 | 8.9 | 2.5 | 5.9 | 72.0 | 71 | 40 | 37 | 8 | 20 | 47 | 0 | 0 | 0 | 0 | 4 | 0 | 1 | 3.97 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 69 | 14 | 14 | 4 | 6 | 4.03 | .301 | 1.24 | 7.8 | 3.4 | 5.8 | 109.1 | 95 | 53 | 49 | 12 | 41 | 70 | 3 | 0 | 0 | 1 | 6 | 5 | 2 | 4.41 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 14 | 14 | 3 | 7 | 5.21 | .344 | 1.56 | 9.2 | 4.9 | 5.0 | 77.2 | 79 | 48 | 45 | 6 | 42 | 43 | 0 | 0 | 0 | 0 | 5 | 1 | 1 | 4.57 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 35 | 0 | 9 | 1 | 4.34 | .259 | 0.99 | 7.3 | 1.7 | 8.6 | 47.2 | 38 | 24 | 23 | 6 | 9 | 45 | 0 | 1 | 2 | 0 | 0 | 3 | 0 | 3.51 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 31 | 0 | 2 | 1 | 4.30 | .280 | 1.14 | 7.8 | 2.7 | 4.6 | 37.2 | 32 | 18 | 18 | 8 | 11 | 19 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 5.76 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 22 | 0 | 1 | 2 | 3.80 | .253 | 1.01 | 6.3 | 3.1 | 8.2 | 23.2 | 16 | 11 | 10 | 3 | 8 | 21 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 3.91 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 54 | 15 | 0 | 0 | 0 | 4.70 | .361 | 1.70 | 9.4 | 5.9 | 7.0 | 23.0 | 24 | 15 | 12 | 3 | 15 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.09 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 1 | 0 | 0 | 1 | 2.08 | .188 | 0.69 | 6.8 | 0.0 | 15.8 | 4.1 | 3 | 1 | 1 | 1 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.75 |