| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 92 | 33 | 33 | 9 | 12 | 4.18 | .291 | 1.22 | 8.7 | 2.3 | 7.3 | 185.0 | 178 | 88 | 86 | 19 | 47 | 150 | 0 | 0 | 0 | 0 | 19 | 3 | 4 | 3.52 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 32 | 32 | 11 | 7 | 3.74 | .276 | 1.12 | 8.0 | 2.1 | 4.1 | 204.1 | 182 | 89 | 85 | 15 | 47 | 92 | 1 | 0 | 0 | 0 | 20 | 5 | 0 | 3.82 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 31 | 31 | 17 | 5 | 3.91 | .292 | 1.21 | 8.2 | 2.6 | 7.8 | 191.0 | 175 | 85 | 83 | 22 | 56 | 165 | 0 | 0 | 0 | 0 | 18 | 5 | 3 | 3.73 |
| SP | Ryan, N.Ryan, Nolan † $ >> | 44 | 1991 | R | 73 | 31 | 31 | 17 | 6 | 3.08 | .281 | 1.16 | 6.4 | 4.0 | 8.3 | 225.0 | 161 | 80 | 77 | 15 | 100 | 208 | 3 | 0 | 0 | 2 | 23 | 3 | 5 | 3.39 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 41 | 29 | 29 | 10 | 14 | 4.48 | .304 | 1.29 | 8.3 | 3.3 | 7.8 | 205.0 | 189 | 114 | 102 | 23 | 76 | 178 | 8 | 0 | 0 | 0 | 14 | 4 | 7 | 3.89 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 76 | 0 | 7 | 4 | 3.76 | .282 | 1.15 | 8.8 | 1.6 | 7.0 | 91.0 | 89 | 40 | 38 | 7 | 16 | 71 | 0 | 11 | 3 | 0 | 0 | 2 | 0 | 3.03 |
| RP | Hader, J.Hader, Josh $ >> | 24 | 2018 | L | 94 | 52 | 0 | 1 | 2 | 3.78 | .303 | 1.27 | 7.0 | 4.5 | 11.0 | 64.1 | 50 | 28 | 27 | 8 | 32 | 78 | 0 | 7 | 0 | 0 | 0 | 2 | 0 | 3.78 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 37 | 0 | 5 | 1 | 3.05 | .295 | 1.26 | 6.4 | 5.0 | 8.6 | 41.1 | 29 | 14 | 14 | 4 | 23 | 39 | 0 | 7 | 1 | 0 | 0 | 0 | 5 | 4.05 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 18 | 0 | 2 | 0 | 4.43 | .272 | 1.07 | 8.2 | 1.6 | 5.3 | 22.1 | 20 | 11 | 11 | 3 | 4 | 13 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.27 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 32 | 0 | 4 | 4 | 3.27 | .273 | 1.13 | 6.6 | 3.6 | 7.4 | 52.1 | 38 | 19 | 19 | 5 | 21 | 43 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.81 |