| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 18 | 18 | 9 | 7 | 4.25 | .284 | 1.16 | 7.7 | 2.8 | 9.7 | 114.1 | 98 | 56 | 54 | 16 | 35 | 123 | 0 | 0 | 0 | 0 | 10 | 3 | 0 | 3.67 |
| SP | Brown, M.Brown, Mordecai # >> | 32 | 1908 | R | 85 | 16 | 16 | 7 | 5 | 4.42 | .320 | 1.37 | 9.3 | 3.2 | 4.4 | 99.2 | 102 | 50 | 49 | 8 | 35 | 48 | 0 | 0 | 0 | 0 | 9 | 4 | 0 | 4.26 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 42 | 0 | 2 | 7 | 3.69 | .302 | 1.25 | 7.0 | 4.3 | 9.4 | 46.1 | 36 | 20 | 19 | 10 | 22 | 48 | 0 | 18 | 2 | 0 | 0 | 2 | 1 | 5.30 |
| SU | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 48 | 0 | 5 | 2 | 4.42 | .275 | 1.08 | 6.6 | 3.2 | 9.2 | 59.0 | 43 | 29 | 29 | 9 | 21 | 60 | 0 | 1 | 3 | 0 | 0 | 3 | 3 | 4.17 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 46 | 0 | 1 | 0 | 3.98 | .345 | 1.58 | 9.6 | 4.6 | 8.2 | 43.0 | 46 | 20 | 19 | 5 | 22 | 39 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 4.23 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 39 | 0 | 1 | 1 | 3.33 | .289 | 1.20 | 7.0 | 3.7 | 9.8 | 46.0 | 36 | 18 | 17 | 4 | 19 | 50 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 3.26 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 54 | 0 | 5 | 0 | 4.35 | .302 | 1.30 | 8.3 | 3.5 | 6.5 | 51.2 | 47 | 26 | 25 | 7 | 20 | 37 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 4.51 |