| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 33 | 33 | 16 | 8 | 3.71 | .281 | 1.16 | 7.6 | 2.8 | 9.3 | 206.1 | 175 | 91 | 85 | 25 | 64 | 212 | 2 | 0 | 0 | 1 | 25 | 3 | 0 | 3.50 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 31 | 31 | 5 | 13 | 4.75 | .311 | 1.34 | 8.8 | 3.3 | 8.5 | 170.2 | 167 | 93 | 90 | 26 | 62 | 160 | 2 | 0 | 0 | 1 | 13 | 2 | 1 | 4.24 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 33 | 31 | 7 | 17 | 6.44 | .363 | 1.67 | 10.8 | 4.2 | 5.1 | 162.0 | 195 | 126 | 116 | 30 | 75 | 92 | 1 | 0 | 1 | 1 | 7 | 7 | 9 | 5.79 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 33 | 31 | 5 | 17 | 5.57 | .362 | 1.70 | 11.3 | 4.1 | 6.1 | 171.1 | 214 | 124 | 106 | 32 | 77 | 116 | 3 | 0 | 0 | 1 | 12 | 1 | 4 | 5.44 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 31 | 30 | 8 | 9 | 6.30 | .356 | 1.63 | 10.7 | 4.0 | 6.6 | 158.2 | 188 | 123 | 111 | 28 | 70 | 115 | 0 | 0 | 0 | 0 | 9 | 5 | 1 | 5.27 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 87 | 0 | 6 | 9 | 4.26 | .300 | 1.27 | 8.3 | 3.2 | 9.8 | 99.1 | 91 | 48 | 47 | 14 | 35 | 108 | 0 | 30 | 6 | 0 | 0 | 2 | 1 | 3.78 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 93 | 0 | 3 | 6 | 4.29 | .303 | 1.26 | 7.1 | 4.3 | 9.8 | 113.1 | 89 | 58 | 54 | 12 | 54 | 123 | 0 | 2 | 4 | 0 | 0 | 5 | 0 | 3.77 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 85 | 0 | 7 | 2 | 3.49 | .300 | 1.27 | 7.2 | 4.2 | 9.6 | 98.0 | 78 | 38 | 38 | 11 | 46 | 105 | 0 | 0 | 6 | 0 | 0 | 2 | 6 | 3.79 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 73 | 0 | 9 | 2 | 4.89 | .331 | 1.44 | 7.8 | 5.3 | 9.2 | 95.2 | 82 | 54 | 52 | 6 | 56 | 97 | 0 | 1 | 1 | 0 | 0 | 4 | 6 | 3.67 |