| SP | Scherzer, M.Scherzer, Max >> | 38 | 2022 | R | 83 | 16 | 16 | 6 | 5 | 3.58 | .305 | 1.32 | 8.9 | 2.9 | 8.2 | 98.0 | 97 | 41 | 39 | 10 | 32 | 89 | 0 | 0 | 0 | 0 | 10 | 0 | 2 | 3.49 |
| SP | Martinez, P.Martinez, Pedro # >> | 34 | 2005 | R | 82 | 15 | 15 | 7 | 6 | 4.81 | .296 | 1.24 | 8.0 | 3.2 | 8.4 | 88.0 | 78 | 48 | 47 | 10 | 31 | 82 | 1 | 0 | 0 | 1 | 6 | 2 | 0 | 3.74 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 81 | 16 | 16 | 8 | 4 | 3.47 | .278 | 1.16 | 8.0 | 2.4 | 8.3 | 111.2 | 99 | 43 | 43 | 8 | 30 | 102 | 1 | 0 | 0 | 1 | 12 | 0 | 2 | 2.91 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 67 | 15 | 15 | 10 | 4 | 3.65 | .312 | 1.35 | 7.7 | 4.5 | 8.7 | 91.1 | 78 | 37 | 37 | 10 | 45 | 88 | 1 | 0 | 0 | 0 | 10 | 1 | 0 | 4.01 |
| SP | Verrett, L.Verrett, Logan >> | 25 | 2015 | R | 92 | 15 | 15 | 0 | 2 | 3.47 | .324 | 1.44 | 9.0 | 4.1 | 5.9 | 46.2 | 46 | 18 | 18 | 4 | 21 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.20 |
| RP | Wagner, B.Wagner, Billy >> | 37 | 2008 | L | 61 | 28 | 0 | 2 | 0 | 2.63 | .294 | 1.25 | 7.3 | 4.1 | 10.2 | 37.2 | 30 | 11 | 11 | 2 | 17 | 42 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 2.81 |
| RP | Núnez, D.Núnez, Dedniel >> | 28 | 2024 | R | 60 | 30 | 0 | 3 | 2 | 0.92 | .219 | 0.84 | 6.5 | 1.2 | 7.4 | 39.1 | 28 | 5 | 4 | 2 | 5 | 32 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 2.41 |
| RP | Robles, H.Robles, Hansel >> | 24 | 2015 | R | 45 | 16 | 0 | 0 | 3 | 3.71 | .261 | 1.06 | 5.3 | 4.2 | 10.1 | 17.0 | 10 | 8 | 7 | 2 | 8 | 19 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 3.71 |
| RP | Richardson, G.Richardson, Gordie >> | 27 | 1965 | L | 32 | 16 | 0 | 0 | 1 | 4.58 | .280 | 1.17 | 9.5 | 1.4 | 8.1 | 19.2 | 20 | 11 | 10 | 3 | 3 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.74 |
| CL | deGrom, J.deGrom, Jacob >> | 34 | 2022 | R | 86 | 36 | 0 | 3 | 2 | 3.86 | .288 | 1.18 | 8.6 | 2.1 | 9.5 | 67.2 | 64 | 29 | 29 | 14 | 16 | 71 | 0 | 11 | 3 | 0 | 0 | 2 | 0 | 4.40 |