| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 95 | 30 | 30 | 11 | 7 | 4.05 | .305 | 1.30 | 7.7 | 4.1 | 9.1 | 182.0 | 155 | 86 | 82 | 19 | 82 | 185 | 0 | 0 | 0 | 0 | 15 | 3 | 0 | 3.73 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 89 | 29 | 29 | 12 | 10 | 3.84 | .312 | 1.34 | 8.9 | 3.2 | 9.1 | 222.2 | 220 | 97 | 95 | 18 | 78 | 224 | 10 | 0 | 0 | 1 | 17 | 5 | 4 | 3.16 |
| SP | Perez, P.Perez, Pascual # >> | 31 | 1988 | R | 73 | 28 | 28 | 13 | 9 | 4.12 | .298 | 1.25 | 8.2 | 3.0 | 5.6 | 203.0 | 186 | 97 | 93 | 22 | 67 | 126 | 4 | 0 | 0 | 1 | 16 | 6 | 7 | 4.25 |
| SP | Strasburg, S.Strasburg, Stephen # >> | 24 | 2013 | R | 65 | 28 | 28 | 10 | 11 | 5.31 | .340 | 1.53 | 9.6 | 4.2 | 8.4 | 164.1 | 175 | 99 | 97 | 19 | 77 | 153 | 0 | 0 | 0 | 0 | 13 | 2 | 2 | 4.09 |
| SP | Martinez, D.Martinez, Dennis >> | 37 | 1992 | R | 62 | 27 | 27 | 9 | 14 | 5.39 | .355 | 1.61 | 10.9 | 3.7 | 5.8 | 175.1 | 212 | 108 | 105 | 21 | 71 | 112 | 2 | 0 | 0 | 0 | 12 | 6 | 7 | 4.60 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 100 | 76 | 0 | 9 | 2 | 2.29 | .253 | 1.01 | 6.2 | 2.9 | 9.3 | 94.1 | 65 | 26 | 24 | 7 | 30 | 97 | 0 | 2 | 3 | 0 | 0 | 1 | 2 | 2.89 |
| RP | Reardon, J.Reardon, Jeff † >> | 26 | 1981 | R | 91 | 82 | 0 | 6 | 3 | 2.31 | .247 | 0.96 | 6.2 | 2.5 | 5.0 | 93.2 | 64 | 26 | 24 | 9 | 26 | 52 | 0 | 9 | 3 | 0 | 0 | 2 | 2 | 4.04 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 89 | 47 | 0 | 4 | 4 | 3.52 | .327 | 1.46 | 9.8 | 3.3 | 8.2 | 46.0 | 50 | 19 | 18 | 8 | 17 | 42 | 0 | 7 | 1 | 0 | 0 | 0 | 1 | 4.54 |
| RP | Albers, M.Albers, Matt >> | 34 | 2017 | R | 85 | 29 | 0 | 2 | 2 | 2.86 | .274 | 1.09 | 7.4 | 2.6 | 8.4 | 28.1 | 23 | 11 | 9 | 2 | 8 | 26 | 0 | 6 | 0 | 0 | 0 | 1 | 0 | 3.04 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 82 | 17 | 0 | 0 | 1 | 3.63 | .333 | 1.44 | 9.0 | 4.2 | 10.6 | 17.1 | 17 | 7 | 7 | 0 | 8 | 20 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.24 |
| RP | Rivero, F.Rivero, Felipe >> | 23 | 2015 | L | 51 | 66 | 0 | 0 | 3 | 4.70 | .343 | 1.51 | 9.7 | 4.0 | 5.4 | 38.1 | 41 | 22 | 20 | 7 | 17 | 23 | 0 | 11 | 1 | 0 | 0 | 2 | 1 | 5.68 |