| SP | Koufax, S.Koufax, Sandy $$ >> | 30 | 1965 | L | 97 | 36 | 36 | 14 | 11 | 4.34 | .296 | 1.24 | 9.0 | 2.2 | 8.1 | 257.0 | 256 | 132 | 124 | 33 | 63 | 230 | 6 | 0 | 0 | 1 | 21 | 5 | 5 | 3.67 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 11 | 15 | 5.97 | .330 | 1.47 | 9.9 | 3.3 | 8.1 | 208.0 | 229 | 145 | 138 | 38 | 76 | 187 | 0 | 0 | 0 | 0 | 12 | 3 | 4 | 4.72 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 33 | 33 | 13 | 12 | 3.38 | .289 | 1.19 | 7.8 | 2.9 | 3.6 | 242.2 | 209 | 95 | 91 | 21 | 79 | 98 | 5 | 0 | 0 | 2 | 22 | 8 | 3 | 4.40 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 33 | 33 | 10 | 13 | 6.16 | .349 | 1.57 | 11.6 | 2.6 | 6.1 | 222.0 | 285 | 160 | 152 | 48 | 63 | 150 | 3 | 0 | 0 | 0 | 9 | 9 | 3 | 5.43 |
| SP | Clemens, R.Clemens, Roger † $$ >> | 24 | 1986 | R | 69 | 30 | 30 | 13 | 16 | 4.95 | .320 | 1.41 | 8.5 | 4.2 | 5.6 | 214.1 | 203 | 127 | 118 | 35 | 99 | 134 | 7 | 0 | 0 | 1 | 12 | 1 | 5 | 5.28 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 75 | 0 | 6 | 4 | 5.51 | .357 | 1.66 | 9.7 | 5.3 | 7.9 | 83.1 | 89 | 51 | 51 | 8 | 49 | 73 | 0 | 2 | 2 | 0 | 0 | 1 | 8 | 4.30 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 75 | 0 | 5 | 7 | 3.05 | .273 | 1.11 | 7.9 | 2.2 | 9.6 | 73.2 | 64 | 25 | 25 | 7 | 18 | 78 | 0 | 40 | 4 | 0 | 0 | 1 | 1 | 2.89 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 74 | 52 | 0 | 1 | 1 | 4.19 | .335 | 1.49 | 6.6 | 7.0 | 8.7 | 53.2 | 39 | 25 | 25 | 8 | 41 | 51 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 5.42 |
| SP | Spahn, W.Spahn, Warren >> | 32 | 1953 | L | 20 | 7 | 2 | 4 | 1 | 6.06 | .355 | 1.65 | 11.3 | 3.9 | 2.3 | 16.1 | 20 | 11 | 11 | 4 | 7 | 4 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 7.06 |