| SP | Tiant, L.Tiant, Luis $$ >> | 28 | 1968 | R | 97 | 27 | 27 | 8 | 11 | 4.04 | .317 | 1.39 | 8.8 | 3.7 | 7.6 | 187.1 | 183 | 94 | 84 | 18 | 77 | 158 | 4 | 0 | 0 | 1 | 16 | 1 | 3 | 3.81 |
| SP | Santana, J.Santana, Johan $$ >> | 25 | 2004 | L | 86 | 26 | 26 | 7 | 15 | 4.87 | .315 | 1.35 | 8.9 | 3.3 | 8.7 | 168.1 | 166 | 104 | 91 | 26 | 61 | 162 | 2 | 0 | 0 | 2 | 11 | 5 | 5 | 4.26 |
| SP | Mathewson, C.Mathewson, Christy † $$ >> | 28 | 1908 | R | 83 | 26 | 26 | 14 | 9 | 2.83 | .275 | 1.11 | 7.6 | 2.4 | 4.5 | 197.0 | 166 | 71 | 62 | 16 | 53 | 99 | 10 | 0 | 0 | 2 | 20 | 5 | 0 | 3.93 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 25 | 25 | 6 | 8 | 5.47 | .338 | 1.54 | 10.5 | 3.3 | 4.0 | 128.1 | 150 | 79 | 78 | 15 | 47 | 57 | 0 | 0 | 0 | 0 | 8 | 0 | 2 | 4.73 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 24 | 24 | 8 | 8 | 6.02 | .331 | 1.48 | 10.6 | 2.7 | 4.3 | 151.0 | 178 | 103 | 101 | 20 | 46 | 72 | 2 | 0 | 0 | 1 | 8 | 0 | 1 | 4.68 |
| CL | Jansen, K.Jansen, Kenley $$ >> | 28 | 2016 | R | 97 | 59 | 0 | 4 | 3 | 4.13 | .320 | 1.36 | 9.0 | 3.4 | 9.3 | 56.2 | 56 | 28 | 26 | 4 | 21 | 58 | 0 | 8 | 4 | 0 | 0 | 3 | 2 | 3.14 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 29 | 0 | 3 | 4 | 3.18 | .266 | 1.03 | 5.8 | 3.4 | 5.8 | 34.0 | 22 | 13 | 12 | 1 | 13 | 22 | 0 | 5 | 2 | 0 | 0 | 2 | 3 | 3.41 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 69 | 16 | 0 | 3 | 1 | 4.71 | .330 | 1.48 | 9.0 | 4.3 | 12.0 | 21.0 | 21 | 15 | 11 | 3 | 10 | 28 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 3.62 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 11 | 0 | 1 | 0 | 2.41 | .243 | 0.96 | 6.0 | 3.0 | 1.5 | 18.2 | 12 | 5 | 5 | 0 | 6 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.67 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 17 | 0 | 1 | 0 | 3.78 | .306 | 1.32 | 7.9 | 4.5 | 5.6 | 16.2 | 14 | 7 | 7 | 3 | 8 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.69 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 18 | 0 | 1 | 0 | 5.74 | .343 | 1.55 | 10.1 | 3.9 | 5.4 | 58.0 | 65 | 37 | 37 | 8 | 25 | 35 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 4.93 |