| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 12 | 12 | 4 | 7 | 4.29 | .271 | 1.10 | 8.7 | 1.3 | 9.2 | 86.0 | 83 | 47 | 41 | 13 | 12 | 88 | 2 | 0 | 0 | 0 | 7 | 1 | 3 | 3.37 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 12 | 12 | 7 | 1 | 3.18 | .274 | 1.11 | 6.4 | 3.6 | 6.4 | 82.0 | 58 | 33 | 29 | 10 | 33 | 58 | 0 | 0 | 0 | 0 | 8 | 2 | 1 | 4.45 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 12 | 12 | 6 | 5 | 3.54 | .311 | 1.36 | 9.0 | 3.2 | 7.3 | 86.1 | 86 | 36 | 34 | 6 | 31 | 70 | 2 | 0 | 0 | 0 | 9 | 0 | 8 | 3.36 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 29 | 0 | 0 | 1 | 4.28 | .279 | 1.16 | 7.6 | 3.0 | 7.4 | 33.2 | 28 | 17 | 16 | 7 | 11 | 27 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 5.12 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 20 | 0 | 1 | 0 | 2.60 | .325 | 1.38 | 7.9 | 4.8 | 5.3 | 17.1 | 15 | 5 | 5 | 0 | 9 | 10 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 3.59 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 12 | 0 | 3 | 0 | 1.15 | .299 | 1.28 | 6.6 | 5.4 | 6.6 | 15.2 | 11 | 2 | 2 | 2 | 9 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.07 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 15 | 0 | 0 | 2 | 2.55 | .321 | 1.38 | 4.9 | 7.9 | 7.9 | 24.2 | 13 | 7 | 7 | 0 | 21 | 21 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.00 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 4 | 0 | 2 | 0 | 2.51 | .232 | 0.91 | 5.8 | 2.6 | 9.0 | 14.1 | 9 | 4 | 4 | 1 | 4 | 14 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.79 |