| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 7 | 7 | 3 | 1 | 3.89 | .294 | 1.23 | 8.8 | 2.3 | 9.0 | 44.0 | 43 | 19 | 19 | 8 | 11 | 44 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 4.18 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 8 | 7 | 2 | 3 | 5.93 | .371 | 1.73 | 10.8 | 4.7 | 5.3 | 44.0 | 53 | 30 | 29 | 9 | 23 | 26 | 1 | 0 | 0 | 0 | 2 | 2 | 1 | 6.18 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 7 | 7 | 2 | 4 | 4.34 | .318 | 1.40 | 9.6 | 3.2 | 7.8 | 45.2 | 48 | 23 | 22 | 7 | 16 | 39 | 2 | 0 | 0 | 0 | 4 | 0 | 0 | 4.36 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 7 | 6 | 1 | 4 | 5.54 | .391 | 1.88 | 11.4 | 5.6 | 6.8 | 37.1 | 47 | 36 | 23 | 4 | 23 | 28 | 0 | 0 | 1 | 0 | 3 | 2 | 1 | 4.92 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 14 | 0 | 2 | 1 | 6.46 | .313 | 1.37 | 9.6 | 3.0 | 8.4 | 15.1 | 16 | 11 | 11 | 7 | 5 | 14 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 8.20 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 15 | 0 | 2 | 0 | 1.42 | .208 | 0.79 | 5.7 | 1.4 | 8.1 | 19.0 | 12 | 4 | 3 | 1 | 3 | 17 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.37 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 17 | 0 | 1 | 1 | 1.57 | .250 | 1.00 | 6.7 | 2.3 | 7.8 | 23.0 | 17 | 4 | 4 | 1 | 6 | 20 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.61 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 80 | 15 | 0 | 1 | 0 | 7.90 | .406 | 1.98 | 13.8 | 4.8 | 13.2 | 13.2 | 20 | 13 | 12 | 4 | 7 | 19 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.92 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 19 | 0 | 0 | 2 | 2.33 | .284 | 1.14 | 4.7 | 5.7 | 7.6 | 19.1 | 10 | 6 | 5 | 3 | 12 | 16 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 5.42 |