| SP | Rodon, C.Rodon, Carlos >> | 28 | 2021 | L | 100 | 23 | 23 | 11 | 7 | 4.04 | .303 | 1.29 | 8.3 | 3.3 | 9.4 | 149.1 | 138 | 71 | 67 | 15 | 54 | 156 | 1 | 0 | 0 | 1 | 12 | 3 | 6 | 3.36 |
| RP | Hendriks, L.Hendriks, Liam >> | 32 | 2021 | R | 98 | 64 | 0 | 3 | 2 | 3.98 | .296 | 1.20 | 8.7 | 2.1 | 11.3 | 63.1 | 61 | 28 | 28 | 7 | 15 | 79 | 0 | 3 | 2 | 0 | 0 | 4 | 3 | 2.84 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 96 | 44 | 0 | 2 | 4 | 4.57 | .340 | 1.48 | 8.4 | 5.0 | 10.7 | 43.1 | 40 | 24 | 22 | 8 | 24 | 51 | 0 | 5 | 5 | 0 | 0 | 3 | 3 | 4.93 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 94 | 32 | 0 | 2 | 4 | 3.16 | .265 | 1.03 | 7.5 | 1.7 | 9.7 | 37.0 | 31 | 13 | 13 | 5 | 7 | 40 | 0 | 7 | 3 | 0 | 0 | 2 | 1 | 3.32 |
| RP | Hernandez, R.Hernandez, Roberto >> | 28 | 1992 | R | 88 | 18 | 0 | 1 | 2 | 3.00 | .341 | 1.56 | 8.5 | 5.5 | 8.0 | 18.0 | 17 | 6 | 6 | 2 | 11 | 16 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 4.50 |
| RP | Lopez, R.Lopez, Reynaldo >> | 27 | 2021 | R | 86 | 16 | 0 | 1 | 0 | 0.48 | .233 | 0.86 | 4.0 | 4.0 | 8.0 | 18.2 | 8 | 1 | 1 | 0 | 8 | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.72 |
| RP | Bummer, A.Bummer, Aaron >> | 27 | 2021 | L | 49 | 60 | 0 | 2 | 2 | 3.04 | .276 | 1.12 | 6.1 | 4.0 | 10.3 | 47.1 | 32 | 20 | 16 | 7 | 21 | 54 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.04 |