| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 25 | 25 | 8 | 8 | 3.53 | .289 | 1.19 | 8.1 | 2.7 | 6.7 | 186.0 | 167 | 75 | 73 | 19 | 55 | 139 | 5 | 0 | 0 | 2 | 13 | 5 | 2 | 3.80 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 24 | 24 | 11 | 6 | 3.38 | .268 | 1.06 | 7.3 | 2.2 | 4.6 | 176.0 | 143 | 66 | 66 | 9 | 43 | 90 | 1 | 0 | 0 | 1 | 16 | 7 | 1 | 3.49 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 24 | 24 | 8 | 9 | 4.09 | .286 | 1.18 | 8.5 | 2.0 | 7.2 | 176.0 | 167 | 85 | 80 | 25 | 40 | 140 | 4 | 0 | 0 | 0 | 13 | 4 | 4 | 4.01 |
| CL | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 44 | 0 | 1 | 7 | 2.17 | .246 | 0.96 | 7.5 | 1.3 | 7.2 | 70.2 | 58 | 18 | 17 | 2 | 10 | 56 | 0 | 11 | 5 | 0 | 0 | 1 | 0 | 2.24 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 63 | 0 | 1 | 0 | 2.09 | .259 | 0.98 | 4.6 | 4.2 | 10.9 | 43.0 | 22 | 10 | 10 | 6 | 20 | 52 | 0 | 3 | 0 | 0 | 0 | 3 | 2 | 4.00 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 38 | 0 | 2 | 2 | 3.70 | .324 | 1.44 | 9.8 | 3.4 | 5.6 | 24.1 | 26 | 12 | 10 | 5 | 9 | 15 | 0 | 6 | 2 | 0 | 0 | 0 | 0 | 5.58 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 50 | 26 | 0 | 0 | 2 | 1.85 | .247 | 0.99 | 6.0 | 3.0 | 8.6 | 24.1 | 16 | 7 | 5 | 3 | 8 | 23 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.71 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 51 | 7 | 1 | 2 | 0 | 1.82 | .191 | 0.67 | 4.3 | 1.9 | 4.0 | 29.2 | 14 | 6 | 6 | 2 | 6 | 13 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 3.72 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 37 | 19 | 0 | 6 | 3 | 3.78 | .351 | 1.62 | 10.1 | 5.1 | 11.3 | 16.2 | 18 | 7 | 7 | 2 | 9 | 20 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.81 |