| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 15 | 15 | 6 | 2 | 3.20 | .269 | 1.09 | 7.7 | 2.1 | 9.8 | 104.0 | 89 | 40 | 37 | 9 | 24 | 113 | 0 | 0 | 0 | 0 | 9 | 2 | 0 | 2.70 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 78 | 15 | 15 | 7 | 7 | 3.79 | .303 | 1.30 | 8.8 | 2.9 | 5.8 | 116.1 | 113 | 53 | 49 | 10 | 38 | 75 | 10 | 0 | 0 | 0 | 9 | 1 | 0 | 3.84 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 15 | 15 | 5 | 10 | 6.73 | .362 | 1.66 | 11.3 | 3.7 | 4.1 | 95.0 | 119 | 75 | 71 | 14 | 39 | 43 | 2 | 0 | 0 | 0 | 4 | 4 | 3 | 5.37 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 14 | 14 | 6 | 4 | 6.40 | .359 | 1.66 | 11.4 | 3.7 | 4.5 | 95.2 | 120 | 73 | 68 | 19 | 39 | 47 | 4 | 0 | 0 | 0 | 3 | 2 | 0 | 5.91 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 36 | 0 | 1 | 1 | 2.65 | .252 | 1.01 | 6.3 | 2.8 | 8.3 | 54.1 | 38 | 16 | 16 | 7 | 17 | 50 | 0 | 5 | 0 | 0 | 0 | 0 | 1 | 3.78 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 28 | 0 | 4 | 1 | 1.72 | .241 | 0.95 | 4.8 | 4.0 | 10.3 | 36.2 | 19 | 7 | 7 | 4 | 16 | 41 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 3.50 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 21 | 0 | 3 | 2 | 4.10 | .275 | 1.14 | 7.3 | 3.1 | 8.0 | 26.1 | 21 | 12 | 12 | 5 | 9 | 23 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4.77 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 16 | 0 | 3 | 0 | 2.65 | .282 | 1.18 | 5.3 | 5.3 | 3.7 | 17.0 | 10 | 5 | 5 | 2 | 10 | 7 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.47 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 13 | 0 | 0 | 0 | 2.81 | .314 | 1.38 | 8.4 | 3.9 | 7.9 | 16.0 | 15 | 7 | 5 | 2 | 7 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.19 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 13 | 0 | 0 | 0 | 4.50 | .314 | 1.38 | 9.6 | 2.8 | 8.4 | 16.0 | 17 | 8 | 8 | 4 | 5 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.31 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |