| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 9 | 9 | 1 | 7 | 3.59 | .268 | 1.10 | 7.5 | 2.5 | 9.6 | 62.2 | 52 | 27 | 25 | 8 | 17 | 66 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 3.37 |
| SP | Gibson, B.Gibson, Bob # >> | 33 | 1968 | R | 93 | 9 | 9 | 3 | 5 | 5.26 | .314 | 1.34 | 9.6 | 2.6 | 4.1 | 63.1 | 67 | 39 | 37 | 9 | 18 | 29 | 2 | 0 | 0 | 0 | 3 | 2 | 2 | 4.89 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 25 | 0 | 5 | 0 | 3.64 | .331 | 1.48 | 7.8 | 5.9 | 12.7 | 29.2 | 25 | 13 | 12 | 2 | 19 | 41 | 0 | 2 | 0 | 0 | 0 | 0 | 4 | 3.03 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 20 | 0 | 1 | 1 | 2.63 | .287 | 1.21 | 8.0 | 3.0 | 9.0 | 27.1 | 24 | 8 | 8 | 3 | 9 | 27 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.44 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 14 | 0 | 1 | 1 | 6.06 | .364 | 1.71 | 12.9 | 2.8 | 9.6 | 16.1 | 23 | 13 | 11 | 2 | 5 | 17 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.44 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 13 | 0 | 2 | 0 | 1.72 | .299 | 1.28 | 7.8 | 4.2 | 9.6 | 15.2 | 13 | 3 | 3 | 1 | 7 | 16 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.13 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 11 | 0 | 0 | 0 | 1.80 | .224 | 0.87 | 4.2 | 3.6 | 10.2 | 15.0 | 7 | 3 | 3 | 0 | 6 | 17 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1.93 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 4 | 0 | 0 | 1 | 4.76 | .393 | 1.94 | 14.4 | 5.4 | 3.6 | 5.2 | 8 | 3 | 3 | 1 | 3 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 6.60 |