| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 25 | 25 | 9 | 9 | 3.28 | .258 | 1.02 | 7.2 | 2.0 | 9.0 | 164.2 | 132 | 60 | 60 | 17 | 36 | 164 | 1 | 0 | 0 | 0 | 18 | 4 | 0 | 3.08 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 24 | 24 | 10 | 8 | 4.17 | .280 | 1.16 | 7.5 | 3.0 | 8.5 | 159.2 | 133 | 75 | 74 | 20 | 53 | 151 | 1 | 0 | 0 | 0 | 12 | 0 | 4 | 3.74 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 23 | 23 | 7 | 14 | 4.30 | .298 | 1.24 | 8.6 | 2.5 | 7.8 | 152.2 | 146 | 73 | 73 | 22 | 43 | 132 | 4 | 0 | 0 | 3 | 12 | 5 | 4 | 4.09 |
| CL | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 42 | 0 | 1 | 5 | 2.95 | .293 | 1.20 | 6.0 | 4.9 | 9.0 | 42.2 | 28 | 14 | 14 | 4 | 23 | 42 | 0 | 24 | 4 | 0 | 0 | 2 | 2 | 4.02 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 61 | 0 | 0 | 0 | 3.11 | .285 | 1.12 | 7.3 | 2.9 | 7.5 | 37.2 | 30 | 13 | 13 | 6 | 12 | 31 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 4.65 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 43 | 0 | 5 | 2 | 3.34 | .317 | 1.36 | 8.2 | 4.2 | 6.2 | 32.1 | 29 | 14 | 12 | 4 | 15 | 22 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.75 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 46 | 0 | 4 | 2 | 3.62 | .254 | 1.02 | 6.5 | 2.8 | 6.2 | 32.1 | 23 | 13 | 13 | 4 | 10 | 22 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 4.19 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 7 | 0 | 1 | 0 | 1.27 | .210 | 0.80 | 4.7 | 2.6 | 8.1 | 21.1 | 11 | 3 | 3 | 1 | 6 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.67 |