| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 15 | 15 | 11 | 2 | 1.94 | .246 | 0.96 | 7.4 | 1.3 | 3.8 | 120.1 | 98 | 30 | 26 | 6 | 17 | 51 | 3 | 0 | 0 | 1 | 13 | 3 | 0 | 3.30 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 15 | 15 | 6 | 3 | 4.01 | .299 | 1.25 | 8.1 | 3.1 | 4.7 | 110.0 | 99 | 50 | 49 | 13 | 38 | 58 | 4 | 0 | 0 | 1 | 10 | 4 | 2 | 4.63 |
| SP | Waddell, R.Waddell, Rube # >> | 29 | 1905 | L | 67 | 15 | 15 | 7 | 6 | 4.09 | .303 | 1.24 | 8.3 | 2.9 | 5.2 | 103.1 | 95 | 48 | 47 | 12 | 33 | 60 | 2 | 0 | 0 | 1 | 8 | 7 | 2 | 4.51 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 46 | 11 | 9 | 3 | 4 | 4.34 | .307 | 1.31 | 7.5 | 4.4 | 8.0 | 66.1 | 55 | 34 | 32 | 8 | 32 | 59 | 1 | 0 | 0 | 1 | 5 | 1 | 4 | 4.29 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 41 | 0 | 3 | 1 | 2.08 | .273 | 1.07 | 5.8 | 4.0 | 10.6 | 34.2 | 22 | 8 | 8 | 1 | 15 | 40 | 0 | 4 | 3 | 0 | 0 | 2 | 1 | 2.53 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 31 | 0 | 2 | 0 | 1.85 | .215 | 0.78 | 3.8 | 3.4 | 6.0 | 24.1 | 10 | 5 | 5 | 2 | 9 | 16 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.00 |
| CL | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 31 | 0 | 3 | 1 | 2.12 | .244 | 0.97 | 6.6 | 2.1 | 7.7 | 34.0 | 25 | 8 | 8 | 2 | 8 | 29 | 0 | 21 | 2 | 0 | 0 | 0 | 0 | 2.76 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 49 | 13 | 0 | 2 | 0 | 5.40 | .259 | 1.05 | 7.5 | 3.0 | 13.5 | 6.2 | 5 | 4 | 4 | 1 | 2 | 9 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.17 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 15 | 0 | 2 | 0 | 4.82 | .282 | 1.18 | 9.0 | 2.0 | 6.0 | 9.1 | 9 | 5 | 5 | 1 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.78 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 11 | 0 | 0 | 0 | 3.24 | .342 | 1.56 | 9.0 | 5.6 | 11.3 | 8.1 | 8 | 3 | 3 | 0 | 5 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.38 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 12 | 6 | 3 | 2 | 5.54 | .341 | 1.53 | 8.8 | 5.0 | 8.3 | 50.1 | 49 | 31 | 31 | 7 | 28 | 46 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 4.72 |