| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 3 | 3 | 0 | 1 | 2.49 | .244 | 0.97 | 8.1 | 0.9 | 12.0 | 21.2 | 19 | 7 | 6 | 2 | 2 | 28 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 1.86 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 3 | 3 | 0 | 1 | 11.70 | .444 | 2.40 | 17.1 | 4.5 | 5.4 | 10.0 | 19 | 14 | 13 | 2 | 5 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.90 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 9 | 0 | 0 | 2 | 6.75 | .333 | 1.50 | 9.0 | 4.5 | 12.4 | 8.0 | 8 | 6 | 6 | 2 | 4 | 11 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 5.00 |
| SU | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 7 | 0 | 1 | 0 | 5.40 | .405 | 2.04 | 12.4 | 6.8 | 10.1 | 8.1 | 11 | 5 | 5 | 0 | 6 | 9 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 9 | 0 | 1 | 1 | 11.88 | .510 | 3.12 | 20.3 | 9.0 | 9.0 | 8.1 | 18 | 11 | 11 | 1 | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.63 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 67 | 8 | 0 | 0 | 1 | 1.86 | .275 | 1.14 | 8.0 | 3.0 | 10.0 | 9.2 | 8 | 2 | 2 | 0 | 3 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.78 |