| SP | Arrieta, J.Arrieta, Jake † # >> | 29 | 2015 | R | 92 | 32 | 32 | 16 | 8 | 3.36 | .278 | 1.13 | 7.4 | 2.8 | 7.5 | 219.2 | 179 | 84 | 82 | 21 | 69 | 182 | 6 | 0 | 0 | 2 | 22 | 6 | 1 | 3.61 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 31 | 31 | 19 | 8 | 2.89 | .261 | 1.05 | 7.9 | 1.5 | 5.1 | 233.2 | 205 | 84 | 75 | 19 | 40 | 132 | 8 | 0 | 0 | 1 | 24 | 2 | 3 | 3.47 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 30 | 30 | 11 | 9 | 4.12 | .321 | 1.40 | 8.7 | 4.0 | 6.6 | 157.1 | 151 | 75 | 72 | 16 | 69 | 115 | 1 | 0 | 0 | 0 | 18 | 3 | 2 | 4.24 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 85 | 0 | 6 | 8 | 3.55 | .307 | 1.30 | 6.3 | 5.4 | 8.5 | 106.1 | 74 | 48 | 42 | 10 | 64 | 100 | 0 | 12 | 5 | 0 | 0 | 3 | 4 | 4.24 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 76 | 0 | 6 | 1 | 4.16 | .309 | 1.32 | 7.1 | 4.8 | 9.0 | 93.0 | 73 | 44 | 43 | 8 | 50 | 93 | 0 | 8 | 1 | 0 | 0 | 2 | 2 | 3.80 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 61 | 0 | 10 | 3 | 2.51 | .271 | 1.10 | 6.3 | 3.7 | 5.4 | 86.0 | 60 | 27 | 24 | 5 | 35 | 52 | 0 | 6 | 2 | 0 | 0 | 1 | 0 | 3.80 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 46 | 0 | 4 | 0 | 2.76 | .273 | 1.11 | 6.2 | 3.8 | 7.3 | 62.0 | 43 | 19 | 19 | 5 | 26 | 50 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 3.74 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 48 | 0 | 3 | 1 | 2.97 | .251 | 1.01 | 6.6 | 2.6 | 9.0 | 63.2 | 46 | 22 | 21 | 3 | 18 | 63 | 0 | 5 | 0 | 0 | 0 | 0 | 1 | 2.48 |