| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 16 | 16 | 8 | 3 | 2.91 | .263 | 1.04 | 6.2 | 3.2 | 5.7 | 96.0 | 66 | 33 | 31 | 6 | 34 | 61 | 0 | 0 | 0 | 0 | 10 | 3 | 1 | 3.70 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 15 | 15 | 5 | 6 | 2.75 | .257 | 1.04 | 7.0 | 2.3 | 4.9 | 108.0 | 84 | 38 | 33 | 12 | 28 | 59 | 4 | 0 | 0 | 2 | 12 | 0 | 1 | 4.13 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 15 | 15 | 4 | 5 | 5.27 | .311 | 1.33 | 7.7 | 4.3 | 9.0 | 71.2 | 61 | 42 | 42 | 9 | 34 | 71 | 0 | 0 | 0 | 0 | 4 | 2 | 2 | 4.17 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 17 | 14 | 2 | 7 | 5.07 | .326 | 1.44 | 8.5 | 4.4 | 6.5 | 87.0 | 82 | 52 | 49 | 9 | 43 | 63 | 1 | 0 | 0 | 0 | 6 | 1 | 3 | 4.41 |
| RP | Capps, C.Capps, Carter # >> | 24 | 2015 | R | 84 | 41 | 0 | 1 | 3 | 4.36 | .275 | 1.10 | 7.0 | 3.1 | 9.3 | 53.2 | 41 | 26 | 26 | 7 | 18 | 55 | 0 | 6 | 0 | 0 | 0 | 2 | 6 | 3.77 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 40 | 0 | 3 | 5 | 3.92 | .359 | 1.63 | 9.1 | 5.6 | 4.9 | 64.1 | 65 | 31 | 28 | 6 | 40 | 35 | 0 | 3 | 4 | 0 | 0 | 3 | 2 | 5.14 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 32 | 0 | 1 | 1 | 3.41 | .288 | 1.14 | 6.6 | 3.6 | 10.7 | 37.0 | 27 | 15 | 14 | 4 | 15 | 44 | 0 | 7 | 1 | 0 | 0 | 3 | 3 | 3.49 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 26 | 0 | 3 | 5 | 3.31 | .295 | 1.22 | 7.9 | 3.4 | 5.6 | 32.2 | 28 | 13 | 12 | 2 | 12 | 20 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.78 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 23 | 0 | 1 | 0 | 2.55 | .295 | 1.26 | 7.9 | 3.8 | 10.5 | 24.2 | 21 | 12 | 7 | 1 | 10 | 28 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 2.46 |