| SP | Johnson, R.Johnson, Randy >> | 36 | 1999 | L | 100 | 34 | 34 | 16 | 8 | 3.73 | .317 | 1.37 | 9.0 | 3.3 | 8.0 | 246.0 | 247 | 105 | 102 | 18 | 90 | 219 | 9 | 0 | 0 | 2 | 22 | 6 | 4 | 3.34 |
| SP | Beckett, J.Beckett, Josh >> | 25 | 2005 | R | 85 | 33 | 33 | 12 | 11 | 4.82 | .335 | 1.49 | 9.9 | 3.5 | 6.7 | 196.0 | 216 | 112 | 105 | 18 | 77 | 145 | 0 | 0 | 0 | 0 | 14 | 3 | 5 | 3.94 |
| SP | Wacha, M.Wacha, Michael >> | 32 | 2024 | R | 76 | 33 | 32 | 16 | 9 | 4.65 | .331 | 1.47 | 10.0 | 3.3 | 5.1 | 185.2 | 206 | 118 | 96 | 30 | 67 | 104 | 0 | 0 | 0 | 0 | 13 | 2 | 3 | 5.10 |
| SP | Boddicker, M.Boddicker, Mike # >> | 33 | 1990 | R | 51 | 34 | 31 | 12 | 10 | 5.13 | .337 | 1.50 | 10.2 | 3.4 | 5.2 | 194.2 | 219 | 120 | 111 | 26 | 73 | 112 | 5 | 0 | 0 | 3 | 13 | 5 | 6 | 4.79 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 100 | 92 | 0 | 7 | 3 | 2.39 | .263 | 1.06 | 6.9 | 2.7 | 8.8 | 131.2 | 100 | 36 | 35 | 12 | 39 | 128 | 0 | 11 | 4 | 0 | 0 | 2 | 1 | 3.18 |
| RP | Mattson, I.Mattson, Isaac >> | 29 | 2025 | R | 83 | 88 | 0 | 9 | 4 | 3.09 | .291 | 1.23 | 7.3 | 3.8 | 6.6 | 105.0 | 85 | 46 | 36 | 9 | 44 | 77 | 0 | 11 | 2 | 0 | 0 | 0 | 0 | 3.90 |
| RP | Quisenberry, D.Quisenberry, Dan >> | 35 | 1988 | R | 10 | 54 | 0 | 4 | 3 | 6.12 | .353 | 1.60 | 12.2 | 2.4 | 3.9 | 57.1 | 77 | 43 | 39 | 11 | 15 | 25 | 0 | 4 | 2 | 0 | 0 | 2 | 2 | 5.53 |
| RP | Campisi, S.Campisi, Sal >> | 28 | 1970 | R | 8 | 46 | 0 | 2 | 1 | 5.49 | .338 | 1.52 | 8.5 | 5.2 | 4.4 | 57.1 | 54 | 37 | 35 | 6 | 33 | 28 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 5.18 |