| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 16 | 16 | 5 | 3 | 3.49 | .276 | 1.12 | 8.3 | 1.8 | 9.7 | 108.1 | 99 | 43 | 42 | 12 | 22 | 116 | 0 | 0 | 0 | 0 | 11 | 3 | 2 | 2.99 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 82 | 17 | 17 | 3 | 5 | 5.19 | .350 | 1.58 | 11.1 | 3.1 | 7.4 | 78.0 | 96 | 45 | 45 | 12 | 27 | 64 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 4.51 |
| SP | Littell, Z.Littell, Zack >> | 29 | 2025 | R | 65 | 17 | 16 | 7 | 5 | 4.64 | .319 | 1.39 | 10.0 | 2.5 | 7.2 | 99.0 | 110 | 51 | 51 | 12 | 28 | 79 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 3.86 |
| RP | Suarez, R.Suarez, Robert >> | 34 | 2025 | R | 91 | 57 | 0 | 5 | 3 | 4.84 | .276 | 1.06 | 6.8 | 2.8 | 9.5 | 57.2 | 43 | 33 | 31 | 10 | 18 | 60 | 0 | 0 | 2 | 0 | 0 | 5 | 1 | 4.39 |
| RP | Weaver, L.Weaver, Luke † >> | 31 | 2025 | R | 84 | 49 | 0 | 7 | 5 | 4.59 | .264 | 1.06 | 7.1 | 2.5 | 11.6 | 51.0 | 40 | 27 | 26 | 6 | 14 | 66 | 0 | 5 | 2 | 0 | 0 | 1 | 1 | 2.82 |
| RP | Williams, D.Williams, Devin >> | 30 | 2025 | R | 75 | 37 | 0 | 2 | 3 | 3.99 | .324 | 1.41 | 7.8 | 5.0 | 12.6 | 38.1 | 33 | 18 | 17 | 2 | 21 | 53 | 0 | 3 | 5 | 0 | 0 | 1 | 2 | 2.63 |
| RP | Banks, T.Banks, Tanner >> | 33 | 2025 | L | 68 | 51 | 0 | 2 | 1 | 4.41 | .315 | 1.32 | 9.8 | 2.3 | 8.4 | 32.2 | 35 | 16 | 16 | 6 | 8 | 30 | 0 | 3 | 2 | 0 | 0 | 2 | 0 | 4.50 |
| RP | Santana, D.Santana, Dennis >> | 29 | 2025 | R | 92 | 27 | 0 | 1 | 1 | 4.54 | .299 | 1.28 | 7.6 | 4.1 | 8.7 | 33.2 | 28 | 17 | 17 | 5 | 15 | 32 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4.39 |
| RP | Fisher, B.Fisher, Braydon >> | 24 | 2025 | R | 90 | 26 | 0 | 3 | 0 | 1.86 | .281 | 1.07 | 7.4 | 2.2 | 10.9 | 29.0 | 24 | 6 | 6 | 1 | 7 | 35 | 0 | 5 | 0 | 0 | 0 | 3 | 0 | 2.07 |